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The overall goal of my clinical and research professional interests is to deepen our understanding of disorders of fluid, electrolyte, and acid-base balance, as well as the role of sodium and potassium in the pathogenesis of primary hypertension. We have done original investigations that uncovered a number of fundamental issues, some of them listed below, including the determinants of hyperchloremic acidosis in diabetic ketoacidosis; maladaptation of the kidney in both metabolic acidosis and alkalosis; role of normal variations in PCO2 as determinants of plasma bicarbonate; changes in plasma anion gap during acid-base disorders; determinants of the changes in serum potassium in acid-base disorders; changes in bicarbonate space caused by titration of non-bicarbonate buffers; effect of respiratory and metabolic acid-base disorders on carbon dioxide titration curve in vivo; impairment in distal nephron acidification in chronic respiratory acidosis; acid-base patterns in patients with status asthmaticus; role of intracellular pH in acidification by the proton pump in turtle urinary bladder; uniformity of the ventilatory response (ΔPCO2 / ΔHCO3‾) in metabolic acid-base disorders; mechanisms of the arteriovenous acid-base disparity in circulatory failure; impairment of tissues glucose consumption in acidemic states; the salutary effects of modest fluid replacement in the management of diabetic ketoacidosis; impact of acute and chronic respiratory acid-base disorders on preexisting metabolic acidosis; demonstration of an apical chloride conductive pathway and GTP-binding proteins in turtle urinary bladder epithelial cells; mechanism of acetazolamide-induced rise in renal vascular resistance in the intact dog; and the regulation of potassium excretion in chronic renal failure.
Professional Interests
Acid-base and electrolyte disorders
Hypertension
Dialysis
Acute kidney disease
Chronic kidney disease
Professional Interests
Acid-base and electrolyte disorders
Hypertension
Dialysis
Acute kidney disease
Chronic kidney disease
Research Interests
Papers共 100 篇Author StatisticsCo-AuthorSimilar Experts
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The New England journal of medicineno. 16 (2023): 1499-1509
Advances in chronic kidney diseaseno. 4 (2022): 343-354
Journal of the American Society of Nephrology : JASNno. 11 (2021): 2933-2947
Ngoentra Tantranont,Yosu Luque, Mary Hsiao, Claire Haute,Lillian Gaber,Roberto Barrios,Horacio E. Adrogue,Aïssata Niasse,Luan D. Truong
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