Hongjun Zhang

Quantitative Biosciences Merck & Co., Inc

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论文共 17 篇作者统计合作学者相似作者

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Discovery of the First Selective, Small-Molecule GFRα2/3 Inhibitors Through DNA-encoded Library Technology

Shea L. Johnson,Galen Missig, Minghua Wang, Kosalvisal Ouk, Kushali Gupta,Hanh Nho Nguyen,May Fern Toh, Tammy Szu-Yu Ho,David Gray,Hongjun Zhang, Yong Mi Choi-Sledeski,Claude Barberis,David J. Stone,Sokhom Pin,Jongwon Lim

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2024)

引用0浏览0WOS引用

Oxetane Promise Delivered: Discovery of Long-Acting IDO1 Inhibitors Suitable for Q3W Oral or Parenteral Dosing

Derun Li,David L. Sloman,Abdelghani Achab,Hua Zhou,Meredeth A. McGowan,Catherine White,Craig Gibeau,Hongjun Zhang,Qinglin Pu,Indu Bharathan,Brett Hopkins,Kun Liu,Heidi Ferguson,Xavier Fradera,Charles A. Lesburg,Theodore A. Martinot,Ji Qi,Zhiguo J. Song,Jingjun Yin,Huangguang Zhang,Licheng Song,Baoqiang Wan,Suzanne DAddio,Nicolas Solban,J. Richard Miller,Beata Zamlynny,Alan Bass,Elizabeth Freeland, Bridget Ykoruk, Catherine Hilliard,Jude Ferraro,Jin Zhai,Ian Knemeyer,Karin M. Otte,Stella Vincent,Nunzio Sciammetta,Alexander Pasternak,David Jonathan Bennett,Yongxin Han

Journal of Medicinal Chemistry（2022）

引用10浏览0WOS引用

Diminishing GSH-Adduct Formation of Tricyclic Diazepine-based Mutant IDH1 Inhibitors

Chunhui Huang,Christian Fischer,Michelle R. Machacek,Stephane Bogen,Tesfaye Biftu,Xianhai Huang,Michael H. Reutershan,Ryan Otte,Qingmei Hong,Zhicai Wu,Yang Yu, Min Park,Lei Chen,Purakkattle Biju,Ian Knemeyer, Ping Lu,Christopher J. Kochansky,Michael Brendan Hicks,Yong Liu,Roy Helmy,Xavier Fradera,Anthony Donofrio,Josh Close,Matthew L. Maddess,Catherine White,David L. Sloman,Nunzio Sciammetta,Jun Lu,Craig Gibeau,Vladimir Simov,Hongjun Zhang,Peter Fuller,David Witter

ACS Medicinal Chemistry Letters（2022）

引用3浏览0WOS引用

Structure-Based Discovery of Proline-Derived Arginase Inhibitors with Improved Oral Bioavailability for Immuno-Oncology

Min Lu,Hongjun Zhang,Derun Li,Matthew Childers,Qinglin Pu,Rachel L. Palte,Symon Gathiaka,Thomas W. Lyons,Anandan Palani,Peter W. Fan,Peter Spacciapoli,J. Richard Miller,Hyelim Cho,Mangeng Cheng,Kalyan Chakravarthy,Jennifer O'Neil,Padmanabhan Eangoor,Adam Beard,Hai-Young Kim,Josep Sauri,Hakan Gunaydin,David L. Sloman,Phieng Siliphaivanh,Jared Cumming,Christian Fischer

ACS Medicinal Chemistry Letters（2021）

引用15浏览0WOS引用

Utilization of Metabolite Identification and Structural Data to Guide Design of Low-Dose IDO1 Inhibitors

Brett Hopkins,Hongjun Zhang,Indu Bharathan,Derun Li,Qinglin Pu,Hua Zhou,Theodore A. Martinot,Xavier Fradera,Alfred Lammens,Charles A. Lesburg,Ryan D. Cohen,Jeanine Ballard,Ian Knemeyer,Karin Otte,Stella Vincent,J. Richard Miller,Nicolas Solban,Mangeng Cheng,Prasanthi Geda,Nadya Smotrov,Xuelei Song,David Jonathan Bennett,Yongxin Han

ACS Medicinal Chemistry Letters（2021）

引用8浏览0WOS引用

Carbamate and N-Pyrimidine Mitigate Amide Hydrolysis: Structure-Based Drug Design of Tetrahydroquinoline IDO1 Inhibitors

Derun Li,Yongqi Deng,Abdelghani Achab,Indu Bharathan,Brett Andrew Hopkins,Wensheng Yu,Hongjun Zhang,Sulagna Sanyal,Qinglin Pu,Hua Zhou,Kun Liu,Jongwon Lim,Xavier Fradera,Charles A. Lesburg,Alfred Lammens,Theodore A. Martinot,Ryan D. Cohen,Amy C. Doty,Heidi Ferguson,Elliott B. Nickbarg,Mangeng Cheng,Peter Spacciapoli,Prasanthi Geda,Xuelei Song,Nadya Smotrov,Pravien Abeywickrema,Christine Andrews,Chad Chamberlin,Omar Mabrouk,Patrick Curran,Matthew Richards,Peter Saradjian,J. Richard Miller,Ian Knemeyer,Karin M. Otte,Stella Vincent,Nunzio Sciammetta,Alexander Pasternak,David Jonathan Bennett,Yongxin Han

ACS MEDICINAL CHEMISTRY LETTERS（2021）

引用17浏览0WOS引用

SAR Towards Indoline and 3-Azaindoline Classes of IDO1 Inhibitors

Wensheng Yu,Yongqi Deng,Brett Hopkins,Xianhai Huang,David Sloman,Hongjun Zhang,Derun Li,Meredeth A. McGowan,Catherine White,Qinglin Pu,Kun Liu,Xavier Fradera,Charles A. Lesburg,Theo Martinot,Amy Doty,Heidi Ferguson,Elliott B. Nickbarg,Mangeng Cheng,Prasanthi Geda,Xuelei Song,Nadya Smotrov,Pravien Abeywickrema,Christine Andrews,Chad Chamberlin,Omar Mabrouk,Patrick Curran,Matthew Richards,Peter Saradjian,J. Richard Miller,Ian Knemeyer,Karin Otte,Stella Vincent,Nunzio Sciammetta,David Jonathan Bennett,Yongxin Han

Bioorganic & medicinal chemistry letters（2021）

引用8浏览0WOS引用

Innovation in Delivering Synthetically Challenging Bicyclic Arginase Inhibitors to Enhance Immunotherapy

Derun Li,Hongjun Zhang,Thomas W. Lyons,Theodore A. Martinot,Abdelghani Achab,Min Lu,Lisa M. Nogle,Spencer McMinn,Matthew J. Mitcheltree,Matthew Childers,Qinglin Pu,Symon Gathiaka, Anand Palani,Kalyan Chakravarthy,Amy D. DeCastro,Jennifer O'Neil,Roshi Afshar,Nicole C. Walsh,Peter W. Fan,Mangeng Cheng,Richard Miller,Amy Doty,Rachel Palte,Hai-Young Kim,Josep Sauri,Adam Beard,Christopher Brynczka,Christian Fischer

CANCER RESEARCH（2021）

引用1浏览0引用

Comprehensive Strategies to Bicyclic Prolines: Applications in the Synthesis of Potent Arginase Inhibitors

Derun Li,Hongjun Zhang,Thomas W. Lyons,Min Lu,Abdelghani Achab,Qinglin Pu,Matthew Childers,Matthew J. Mitcheltree, Jialiang Wang,Theodore A. Martinot,Spencer E. McMinn,David L. Sloman,Anandan Palani,Adam Beard,Lisa Nogle,Symon Gathiaka,Josep Sauri,Hai-Young Kim,Donovon Adpressa,Peter Spacciapoli,J. Richard Miller,Rachel L. Palte,Charles A. Lesburg,Jared Cumming,Christian Fischer

ACS Medicinal Chemistry Letters（2021）

引用8浏览0WOS引用

Discovery of N-(Indazol-3-yl)piperidine-4-carboxylic Acids As RORγt Allosteric Inhibitors for Autoimmune Diseases

Hongjun Zhang,Blair T. Lapointe,Neville Anthony,Rita Azevedo, Jos Cals,Craig C. Correll,Matthew Daniels,Sujal Deshmukh, Hans van Eenenaam,Heidi Ferguson,Laxminarayan G. Hegde, Willem Jan Karstens,John Maclean,J. Richard Miller,Lily Y. Moy,Vladimir Simov,Sunil Nagpal,Arthur Oubrie,Rachel L. Palte,Gopal Parthasarathy,Nunzio Sciammetta,Mario van der Stelt,Janice D. Woodhouse,B. Wesley Trotter,Kenneth Barr

ACS MEDICINAL CHEMISTRY LETTERS（2020）

引用18浏览0WOS引用

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作者统计

#Papers: 17

#Citation: 228

H-Index: 8

G-Index: 13

Sociability: 5

Diversity: 1

Activity: 7

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