Honghai Zhang

1. XiTing Lian, Qing Xu, YuLing Wang, LeYuan Gu, Qian Yu, WeiHui Shao，HaiXiang Ma，Yue Shen , Lu Liu JiaXuan Gu，HongHai Zhang.Noradrenergic Pathway from the Locus Coeruleus to Heart Is Implicated in Modulating SUDEP. iScience, 2023. DOI:https://doi.org/10.1016/j.isci.2023.106284 (Correspondence to HongHai Zhang) 2.HaiXiang Ma,Qian Yu,Yue Shen,XiTing Lian, LeYuan Gu, YuLing Wang, Qing Xu, Han Lu HaiTing Zhao,Chang Zeng,Kazuki Nagayasu, HongHai Zhang. Dorsal Raphe Nucleus to Pre-Bötzinger Complex Serotonergic Neural Circuit is Involved in Seizure-induced Respiratory Arrest. iScience.2022,DOI:https://doi.org/10.1016/j.isci.2022.105228 (Correspondence to HongHai Zhang) 3.YuLing Wang, Qing Xu, Qian Yu, LeYuan Gu, HaiXiang Ma, Yue Shen, XiTing Lian,WeiHui Shao, JiaXuan Gu, Lu Liu, HongHai Zhang. Protocol for modulation of the serotonergic DR-PBC neural circuit to prevent SUDEP in the acoustic and PTZ-induced DBA/1 mouse models of SUDEP. STAR Procotocls, 2023 DOI: 10.1016/j.xpro.2023.102129, (Correspondence to HongHai Zhang) 4.LeYuan Gu, Qian Yu, Yue Shen, YuLing Wang , Qing Xu, HongHai Zhang. The role of monoaminergic neurons in modulating respiration during sleep and the connection with SUDEP. Biomed Pharmacother. 2022 ;150:112983. doi: 10.1016/j.biopha.2022.112983. (Correspondence to HongHai Zhang) 5.Yue Shen, Hai Xiang Ma, Han Lu, Hai Ting Zhao, Jian Liang Sun, Yuan Cheng, Hong Hai Zhang. Central deficiency of norepinephrine synthesis and norepinephrinergic neurotransmission contributes to seizure-induced respiratory arrest. Biomed Pharmacother. 2021 ;133:111024. doi: 10.1016/j.biopha.2020.111024(Correspondence to HongHai Zhang) 6.Honghai Zhang, Haiting Zhao, Chang Zeng, Christa Van Dort, Carl L Faingold , Norman E Taylor, Ken Solt , Hua-Jun Feng. Optogenetic activation of 5-HT neurons in the dorsal raphe suppresses seizure-induced respiratory arrest and produces anticonvulsant effect in the DBA/1 mouse SUDEP model.Neurobiol Dis. 2018 ;110:47-58. doi: 10.1016/j.nbd.2017.11.003. 7.Haiting Zhao, Honghai Zhang, Frederick J Schoen , Steven C Schachter. Hua-Jun Feng. Repeated generalized seizures can produce calcified cardiac lesions in DBA/1 mice.Epilepsy Behav. 2019; 95:169-174. doi: 10.1016/j.yebeh.2019.04.010. 8.Honghai Zhang, Haiting Zhao, Hua-Jun Feng. Atomoxetine, a norepinephrine reuptake inhibitor, reduces seizure-induced respiratory arrest.Epilepsy Behav. 2017 ;73:6-9. doi: 10.1016/j.yebeh.2017.04.046. 9.Honghai Zhang, Haiting Zhao, Xiaoxuan Yang, Qingsheng Xue, Joseph F Cotten, Hua-Jun Feng. 5-Hydroxytryptophan, a precursor for serotonin synthesis, reduces seizure-induced respiratory arrest.Epilepsia. 2016 ;57(8):1228-35. doi: 10.Zhang HH, Zhang XQ, Xue QS, LuoY, Zhang Su, Hai-Jun Shao, Huang JL, Lu H,Wang WY, Yu BW. The BDNF/TrkB signaling pathway is involved in heat hyperalgesia mediated by Cdk5 in rats. PLoS ONE 2014, 21; 9(1):e85536. 11.Zhang XQ, Zhang HH, ShaoHJ, Xue QS, Yu BW. ERK MAP Kinase Activation in Spinal Cord Regulates Phosphorylation of Cdk5 at Serine 159 and Contributes to Peripheral Inflammatory Pain Hypersensitivity. PLoS ONE 2014, 21;9 (1): e87788 12.Wang WY, Jia LJ, Luo Y, Zhang HH, Cai F, Mao H, Xu WC, Fang JB, Peng ZY, Ma ZW, Chen YH, Zhang J, Wei Z, Yu BW, Hu SF. Location- and Subunit-Specific NMDA Receptors Determine the Developmental Sevoflurane Neurotoxicity Through ERK1/2 Signaling. Mol Neurobiol. 2014 Nov 25 13.Wang WY, Luo Y, Jia LJ, Hu SF, Lou XK, Shen SL, Lu H, Zhang HH, Yang R, Wang H, Ma ZW, Xue QS, Yu BW. Inhibition of aberrant cyclin-dependent kinase 5 activity attenuates isoflurane neurotoxicity in the developing brain. Neuropharmacology, 2013, 18-20. 14.WangWY, WangH, LuoY, JiaLJ. ZhaoJN, Zhang HH, MaZW, XueQS,Y uBW. The effects of metabotropic glutamate receptor 7 allosteric agonist N,N'-dibenzhydrylethane-1,2-diamine dihydrochloride on developmental sevoflurane neurotoxicity: role of extracellular signal-regulated kinase 1 and 2 Mitogen-activated protein kinase signaling pathway. Neuroscience, 2012,15, (205):167-77. 15.Kong F, Chen S, Cheng Y, Ma L, Lu H, Zhang HH, Hu W. Minocycline attenuates cognitive impairment induced by isoflurane anesthesia in aged rats. PLoS ONE. 2013, 16; 8(4):e6138. 16.Sun J, Lu B, Yao J, Lei W, Huang Y, Zhang H, Xiao C. Intra-periaqueductal gray infusion of zeta inhibitory peptide attenuates pain-conditioned place avoidance in rats. Brain Res. 2014 .doi: 10.1016/j.brainres.2014.07.027. [Epub ahead of print] 17.Shao H, Xue Q, Zhang F, Luo Y, Zhu H, Zhang X, Zhang H, Ding W, Yu B. Spinal SIRT1 activation attenuates neuropathic pain in mice. PLoS One. 2014, 24;9(6):e100938. 18.Fei-Juan Kong , Lei-Lei Ma, Hong-Hai Zhang, Jia-Qiang Zhou. Alpha 7 nicotinic acetylcholine receptor agonist GTS-21 mitigates isoflurane-induced cognitive impairment in aged rats . journal of surgical research, 2014 accepted.10.1111/epi.13430.