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The Laboratory of Molecular Theranostics (LMT), led by Hisataka Kobayashi, MD, PhD, is a major basic research section of the Molecular Imaging Branch. It focuses on the development of imaging and theranostic probes with a particular emphasis on optical probes. Since its inception, the LMT has sought to develop probes that could aid in the detection of tumors, for instance, during surgical resections or endoscopy. In the course of investigating new near infrared (NIR) fluorophores we discovered a dye, IRDye700DX (IR700), that when conjugated to an antibody was highly lethal only to targeted cells after NIR light exposure, yet, had almost no off-target toxicity. We termed this phenomenon “near infrared photoimmunotherapy”. Near infrared Photoimmunotherapy (NIR-PIT) is quite different from the conventional photodynamic therapy (PDT), a cancer treatment that has been used for decades with only modest success. In NIR-PIT, the agent must bind to the cell membrane and does not need to be internalized.
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CLINICAL BIOPHOTONICS (2020)
Kohei Nakajima, Toshihiro Kimura,Hideo Takakura, Yasuo Yoshikawa, Atsushi Kameda,Takayuki Shindo,Kazuhide Sato,Hisataka Kobayashi,Mikako Ogawa
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