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个人简介
We are interested in various aspects of organic and bioorganic mass spectrometry. The focus areas include fundamental understanding of gas-phase ion chemistry, and structural characterization of molecules.
Mass spectrometry provides a powerful tool for the analysis of organic and biomolecules. Chemical ionization methods are developed for (1) distinction of isomeric compounds, including hydrocarbons and amino acids, (2) structural characterization of complex molecules, such as synthetic polymers and peptides, and (3) examination of the composition of complex mixtures, especially base oils. Laser-based methods are developed for evaporation of intact neutral bio- and synthetic polymers into mass spectrometers.
Mass spectrometry allows the direct examination of organic and biological reaction intermediates that are difficult to study by other experimental approaches. The information obtained on the molecules' intrinsic properties provides the basis for understanding of their behavior in solution. This work includes the design of gas-phase synthesis strategies, kinetic and thermochemical studies, and molecular orbital calculations on aromatic radicals and biradicals, nucleobase radical cations and ionized carbenes (see figure on the right). The knowledge obtained in these studies aids the understanding of DNA degradation by antitumor drugs and UV irradiation.
Recognitions
Frank H. Field & Joe L. Franklin Award for Outstanding Achievement in Mass Spectrometry, American Chemical Society , 2015
Provost's Award for Outstanding Graduate Faculty Mentor, 2009
Member of The Finnish Academy of Science, 2004
Faculty Scholar, 2001
Career Advancement Award, the National Science Foundation, 1996
Young Faculty Award of Eli Lilly and Company, 1992
American Society for Mass Spectrometry Award, 1991
Finnish Chemical Society Gustaf Komppa Award, 1985
Mass spectrometry provides a powerful tool for the analysis of organic and biomolecules. Chemical ionization methods are developed for (1) distinction of isomeric compounds, including hydrocarbons and amino acids, (2) structural characterization of complex molecules, such as synthetic polymers and peptides, and (3) examination of the composition of complex mixtures, especially base oils. Laser-based methods are developed for evaporation of intact neutral bio- and synthetic polymers into mass spectrometers.
Mass spectrometry allows the direct examination of organic and biological reaction intermediates that are difficult to study by other experimental approaches. The information obtained on the molecules' intrinsic properties provides the basis for understanding of their behavior in solution. This work includes the design of gas-phase synthesis strategies, kinetic and thermochemical studies, and molecular orbital calculations on aromatic radicals and biradicals, nucleobase radical cations and ionized carbenes (see figure on the right). The knowledge obtained in these studies aids the understanding of DNA degradation by antitumor drugs and UV irradiation.
Recognitions
Frank H. Field & Joe L. Franklin Award for Outstanding Achievement in Mass Spectrometry, American Chemical Society , 2015
Provost's Award for Outstanding Graduate Faculty Mentor, 2009
Member of The Finnish Academy of Science, 2004
Faculty Scholar, 2001
Career Advancement Award, the National Science Foundation, 1996
Young Faculty Award of Eli Lilly and Company, 1992
American Society for Mass Spectrometry Award, 1991
Finnish Chemical Society Gustaf Komppa Award, 1985
研究兴趣
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Sebastian Kawa, Jaskiran Kaur,Harald Knorke,Ziyan Warneke, Myriam Wadsack,Markus Rohdenburg,Marc Nierstenhöfer,Carsten Jenne,Hilkka Kenttämaa,Jonas Warneke
The Analyst (2024)
Sebastian Kawa, Jaskiran Kaur,Harald Knorke, Ziyan Warneke, Myriam Wadsack,Markus Rohdenburg, Marc Nierstenhoefer,Carsten Jenne,Hilkka Kenttamaa,Jonas Warneke
Caroline E. R. Rowell, Jaskiran Kaur,Yuyang Zhang,Kawthar Z. Alzarieni, Ruth O. Anyaeche, Hendrik M. Ma, Annika M. Little, Tanya Sharma, Matthan D. Nussbaum, Drake A. Hershberger, Ying-jou Lee,Voislav Blagojevic,
Xin Ma, Ruth O. Anyaeche,Erlu Feng, Erynn Johnson, Ethan Roller, Daniel J. Rumley,John J. Nash,Hilkka I. Kenttamaa
INORGANIC CHEMISTRY FRONTIERSno. 20 (2023): 6032-6044
ISRAEL JOURNAL OF CHEMISTRYno. 7-8 (2023)
Journal of the American Society for Mass Spectrometryno. 3 (2023): 426-434
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