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个人简介
Hidenori Koyama has been focused on the research questions regarding vascular complications in diabetes, through molecular and biological basic studies and clinical studies. As a post-doctoral fellow in the University of Washington, he examined molecular mechanisms for arterial smooth muscle proliferation (Cell 87: 1069, 1996; JCI 100: 875, 1997), and apoptosis of human endothelial cells (J Exp Med 187: 579, 1998; Mol Cell 1: 553, 1998). He continued to examine regulatory mechanisms of arterial smooth muscle cells (Circ Res 88: 460, 2001; ATVB 22: 1286, 2002; ATVB 22: 1573, 2002), with his basic findings were extended to carotid atherosclerosis in diabetic patients (Diabetes 51: 1523, 2002; Circulation 108: 524, 2003). He then examined the importance of AGEs and its receptor, RAGE, in diabetic and non-diabetic vascular complications (ATVB 25: 2587, 2005; Diabetes 55: 2245, 2006; Mol Med 13: 625, 2007; ATVB 27: 147, 2007; Metabolism 57: 1452, 2008; Atherosclerosis 211: 431, 2010; Metabolism 60: 453, 2011; Atherosclerosis 234: 329, 2014), and endothelial inflammation (FASEB J 33:3575-3589, 2019) . Of note, RAGE is found to be involved also in adiposity and metabolic syndrome (ATVB 25: 2587, 2005; Diabetes 62: 478-489, 2013). Recently, his research has been focused on the importance of psycho-social factors (eg. sleep, autonomic function, fatigure) in the pathogenesis of atherosclerosis, heart failure, renal function, obesity, diabetes and cognition. He has organized cohorts (HSCAA and HDHCC) to address these questions (CJASN 5: 659, 2010; Atherosclerosis 238: 409, 2015; Cardiovasc Diabetol 14: 117, 2015; J Neurosci Res 94:424, 2016; Psychoneuroendocrinology 74:7, 2016; Sci Rep 7:44387, 2017; Atherosclerosis 270: 95, 2018; Int J Mol Sci 20, 794, 2019Metabolism Open 5: 100025, 2020; Metabolism Open 6: 100033, 2020).
研究兴趣
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CASE REPORTS IN ENDOCRINOLOGY (2024): 4662803-4662803
JCEM case reportsno. 2 (2024): luae015-luae015
Journal of diabetes investigation (2024)
Chikako Inoue,Yoshiki Kusunoki,Mana Ohigashi,Keiko Osugi,Kazuhiro Kitajima,Ayako Takagi, Maki Inoue, Chisako Yagi,Taku Tsunoda,Miki Kakutani,Manabu Kadoya,Kosuke Konishi,
BMJ OPEN DIABETES RESEARCH & CAREno. 1 (2024)
Dasen Ye,Akio Miyoshi, Tomoe Ushitani,Manabu Kadoya,Masataka Igeta,Kosuke Konishi,Takuhito Shoji,Koubun Yasuda,Shiho Kitaoka,Hideshi Yagi,Etsushi Kuroda,Yasuhiko Yamamoto,
HYPERTENSIONno. 1 (2024): 172-182
medrxiv(2023)
Reviews in endocrine & metabolic disordersno. 2 (2023): 327-343
Ayako Takagi,Yoshiki Kusunoki,Mana Ohigashi,Keiko Osugi, Chikako Inoue, Maki Inoue,Taku Tsunoda,Manabu Kadoya,Kosuke Konishi,Tomoyuki Katsuno,Hidenori Koyama, Hyogo Diabetes Hypoglycemia Cognition Complications (HDHCC) study group
Acta diabetologicano. 4 (2023): 413-423
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