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Regenerative medicine is a challenging scientific field that aims to convert the pioneering knowledge of developmental biology and stem cell biology to clinical application. For patients with end-stage organ failure, organ transplantation is the only effective treatment; however, the paucity of organ for transplantation hinders the treatment of most patients. Therefore, regenerative medicine with transplantable organs has attracted attention. Our laboratory has established novel organoid culture technologies to reconstruct human organs from stem cells, including human induced pluripotent stem cells (iPSCs). We are currently developing a novel therapeutic strategy to substitute organ transplantation. Furthermore, we have applied our established technologies to cancer research and have reconstructed artificial refractory cancer tissue (cancer organoid) with tumor microenvironment. Based on this unique cancer organoid, we are currently developing a new drug-screening system to impede cancer relapse and metastasis.
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论文共 244 篇作者统计合作学者相似作者
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Shunsuke Tabe, Kenta Takeuchi, Kenji Aoshima, Ayumu Okumura, Yuya Yamamoto,Ryotaro Eto,Megumi Matsuo,Yasuharu Ueno,Takanori Konishi,Yoichi Furukawa,Kiyoshi Yamaguchi, Soichiro Morinaga,
crossref(2024)
Yang Li,Yunzhong Nie, Xia Yang, Yang Liu, Xiaoshan Deng, Yoshihito Hayashi, Riana Plummer, Qinglin Li, Na Luo, Toshiharu Kasai, Takashi Okumura, Yu Kamishibahara,
CELL REPORTSno. 3 (2024): 113918-113918
International journal of molecular sciencesno. 8 (2023)
Journal of autoimmunity (2023): 103085-103085
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STAR protocolsno. 3 (2023): 102471-102471
CANCER SCIENCE (2023): 1161-1161
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