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个人简介
Herman Overkleeft is an organic chemist and chemical biologist whose activity-based protein profiling (ABPP) program (Acc Chem Res 2011, 718) is recognized as leading internationally. His lab was the first (coinciding with the Cravatt group) to connect ABPP with bioorthogonal chemistry (van Swieten, Angew Chem Int Ed 2003) and the first to perform three bioorthogonal reactions in a single experiment (Willems, Angew Chem Int Ed 2012). His lab developed a chemoselective linker for chemical proteomics profiling (Geurink, Angew Chem Int Ed, 2009), and lysosomal cysteine protease (cathepsin) ABPs targeted to cells through the mannose receptor (Hillaert, Angew Chem Int Ed, 2010) and the M6P receptor (Hoogendoorn, Angew Chem Int Ed, 2014). The developed inhibitors and activity-based probes are highly sought-after commodities both for application in biomedicine and biotechnology studies. This has led to numerous fruitful collaborations, and to weekly shipments of compounds without strings attached to interested colleagues.
A main focus throughout the years has been the development of inhibitors and activity-based probes for human constitutive proteasomes and immunoproteasomes. This has resulted in a unique set of reagents and tools with which each of the six catalytic activities of the human constitutive proteasome and immunoproteasome combined can be inhibited and visualized (van Swieten, Angew Chem Int Ed 2003; de Bruin, Angew Chem Int Ed 2016; de Bruin, J Am Chem Soc 2016). Key collaborators on proteasome research are Alexei Kisselev (Auburn University, Alabama, USA; biochemistry, enzymology), Michael Groll (Technical University Munich, Germany; enzymology, structural biology) and Christoph Driessen (St Gallen Medical Centre, Switzerland; onco-haematology).
A main focus throughout the years has been the development of inhibitors and activity-based probes for human constitutive proteasomes and immunoproteasomes. This has resulted in a unique set of reagents and tools with which each of the six catalytic activities of the human constitutive proteasome and immunoproteasome combined can be inhibited and visualized (van Swieten, Angew Chem Int Ed 2003; de Bruin, Angew Chem Int Ed 2016; de Bruin, J Am Chem Soc 2016). Key collaborators on proteasome research are Alexei Kisselev (Auburn University, Alabama, USA; biochemistry, enzymology), Michael Groll (Technical University Munich, Germany; enzymology, structural biology) and Christoph Driessen (St Gallen Medical Centre, Switzerland; onco-haematology).
研究兴趣
论文共 883 篇作者统计合作学者相似作者
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Tim P Ofman,Jurriaan J A Heming,Alba Nin-Hill,Florian Küllmer, Elisha Moran,Megan Bennett,Roy Steneker, Anne-Mei Klein,Gijs Ruijgrok,Ken Kok, Zach W B Armstrong,Johannes M F G Aerts,
Chemistry (Weinheim an der Bergstrasse, Germany)no. 31 (2024): e202400723-e202400723
Sander B Engelsma,Aurelio Pio Nardozza, Pieter de Saint Aulaire,Herman S Overkleeft,Gijsbert A van der Marel,Andreas G Ladurner,Dmitri V Filippov
Chembiochem : a European journal of chemical biologyno. 8 (2024): e202300865-e202300865
Tim P. Ofman,Jurriaan J. A. Heming,Alba Nin-Hill,Florian Küllmer, Elisha Moran,Megan Bennett,Roy Steneker, Anne-Mei Klein,Gijs Ruijgrok,Ken Kok, Zach W. B. Armstrong,Johannes M. F. G. Aerts,
Chemistry – A European Journalpp.e202400723-e202400723, (2024)
ANGEWANDTE CHEMIE-INTERNATIONAL EDITIONno. 4 (2024): e202313317-e202313317
Tim P. Ofman,Jurriaan J. A. Heming,Alba Nin-Hill, Florian Kuellmer, Elisha Moran,Megan Bennett,Roy Steneker, Anne-Mei Klein,Gijs Ruijgrok,Ken Kok, Zach W. B. Armstrong,Johannes M. F. G. Aerts,
CHEMISTRY-A EUROPEAN JOURNAL (2024)
CURRENT OPINION IN CHEMICAL BIOLOGY (2024): 102418-102418
Joshua B. Simpson,Morgan E. Walker, Joshua J. Sekela, Samantha M. Ivey,Parth B. Jariwala, Cameron M. Storch, Mark E. Kowalewski,Amanda L. Graboski,Adam D. Lietzan,William G. Walton, Kacey A. Davis,Erica W. Cloer,
Cell Host & Microbeno. 6 (2024): 925-944.e10
Zirui Li, Isabelle B. Pickles,Mahima Sharma, Benjamin Melling, Luise Pallasdies,Jeroen D. C. Codee,Spencer J. Williams,Herman S. Overkleeft,Gideon J. Davies
Paola Paone, Dimitris Latousakis,Romano Terrasi,Didier Vertommen,Ching Jian,Valentina Borlandelli,Francesco Suriano,Malin E V Johansson, Anthony Puel,Caroline Bouzin,Nathalie M Delzenne,Anne Salonen,
Gutpp.gutjnl-2023, (2024)
Conor J. R. Scott,Nicholas G. S. Mcgregor,Daniel R. Leadbeater,Nicola C. Oates, Janina Hossbach,Amira Abood, Alexander Setchfield, Adam Dowle,Herman S. Overkleeft,Gideon J. Davies,Neil C. Bruce
MICROBIOLOGY SPECTRUMno. 7 (2024): e0394323-e0394323
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