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Bio
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The growth and development of eukaryotic organisms is determined by the interactions between their genetic make-up and the environment. At the molecular level this translates into differential gene expression, giving rise to distinctly specialized cells, tissues, and/or organs. Indeed, the complex development of multicellular eukaryotes requires the silencing of many of their genes in different cell types at any given time. Cell and tissue-specific gene inactivation is a characteristic feature of many developmentally regulated genes and is associated with differentiation processes. This gene silencing involves heritable (but reversible) epigenetic mechanisms, in contrast to genetic effects that are based on stable changes at the DNA level. Epigenetic patterns of expression/repression can be altered in response to environmental or physiological signals, repressing genes under conditions where they are not needed and reactivating their expression if internal or external influences change again. Epigenetic mechanisms also play an essential role in defense responses against a variety of intracellular genomic parasites, such as viruses and transposable elements. The long-term goal of our research projects is to understand the molecular basis of these epigenetic phenomena. We are using the unicellular green alga Chlamydomonas reinhardtii and the higher plant Arabidopsis thaliana as model systems to identify and characterize molecular components that determine transcriptional or post-transcriptional gene silencing. We are concentrating on two main areas: RNA-mediated gene silencing and histone modifications associated with euchromatic transcriptional silencing. More recently we have also become interested in the gene regulatory networks that control nonpolar lipid accumulation in microalgae.
Research Interests
Papers共 51 篇Author StatisticsCo-AuthorSimilar Experts
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Phycologyno. 2 (2024): 213-234
Huang Li,Soujanya Akella,Carina Engstler,Joy J. Omini, Moira Rodriguez,Toshihiro Obata,Chris Carrie,Heriberto Cerutti,Jeffrey P. Mower
Nature Communicationsno. 1 (2024): 1-13
In Vitro Cellular & Developmental Biology - Plantno. 6 (2023): 671-683
The Plant cellno. 6 (2023): 1868-1887
bioRxiv (Cold Spring Harbor Laboratory) (2022)
bioRxiv (Cold Spring Harbor Laboratory) (2021)
Plant Physiology (2021)
Drahomíra Faktorová,R. Ellen R. Nisbet, José A. Fernández Robledo,Elena Casacuberta,Lisa Sudek,Andrew E. Allen,Manuel Ares Jr,Cristina Aresté,Cecilia Balestreri,Adrian C. Barbrook, Patrick Beardslee,Sara Bender,
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