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Genes interact in functional gene programs that ultimately constitute health or disease. Gene programs act on the level of individual cells but importantly also at tissue level across multiple cell types. Functionally connected multicellular circuits react as a coordinated unit in immunological responses to environmental challenges and infections. The main aim of this research is to understand how cells are wired together into circuits and thereby influence each other in lung health and disease. We study patient and mouse tissues, and organotypic ex vivo models at single cell resolution. This enables us to reconstruct regulatory cellular circuits and identify fundamental cellular and molecular mechanism of lung disease and regeneration, as well as associated clinically relevant biomarkers.
Genes interact in functional gene programs that ultimately constitute health or disease. Gene programs act on the level of individual cells but importantly also at tissue level across multiple cell types. Functionally connected multicellular circuits react as a coordinated unit in immunological responses to environmental challenges and infections. The main aim of this research is to understand how cells are wired together into circuits and thereby influence each other in lung health and disease. We study patient and mouse tissues, and organotypic ex vivo models at single cell resolution. This enables us to reconstruct regulatory cellular circuits and identify fundamental cellular and molecular mechanism of lung disease and regeneration, as well as associated clinically relevant biomarkers.
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论文共 171 篇作者统计合作学者相似作者
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Donovan Correa-Gallegos,Haifeng Ye,Bikram Dasgupta,Aydan Sardogan,Safwen Kadri, Ravinder Kandi,Ruoxuan Dai,Yue Lin, Robert Kopplin, Disha Shantaram Shenai,Juliane Wannemacher, Ryo Ichijo,
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crossref(2024)
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Carola Voss, Lianyong Han,Meshal Ansari,Maximilian Strunz, Verena Haefner, Carol Ballester-Lopez,Ilias Angelidis,Christoph H Mayr,Trine Berthing,Thomas Conlon, Qiongliang Liu, Hongyu Ren,
biorxiv(2024)
THORAX (2024)
Laurens De Sadeleer,Yuexin Chen, Christoph Jentzsch, Zhenda Wang, Niyeti Qazi,Niklas Lang,Pascal Albanese,Andris Jankevics,Fabian Theis,Richard Scheltema,Wim Wuyts,Janine Gote-Schniering,
EUROPEAN RESPIRATORY JOURNAL (2023)
Yuexin Chen,Janine Gote-Schniering, Michaela Mueller,Pascal Albanese,Andris Jankevics, R. Christoph Jentzsch,Aleksandra Tata,Meshal Ansari,Laurens De Sadeleer,Lin Yang,Lukas Heumos,Ahmed Agami,
EUROPEAN RESPIRATORY JOURNAL (2023)
Lujia Han,Carola Voss,Meshal Ansari,Maximilian Strunz,Ilias Angelidis, Verena Haefner,Christoph H. Mayr, Carolina Ballester, Qiongliang Liu,Ali Önder Yildirim,Thomas M. Conlon,Ulla Voger,
Annals of Work Exposures and Healthno. Supplement_1 (2023): i59-i60
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biorxiv(2023)
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