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Research in the Dohlman Lab is centered on G proteins and G protein-coupled receptors (GPCRs). GPCRs are the target of many pharmaceuticals, hormones and neurotransmitters, as well as most environmental signals. Generally speaking, persistent stimulation of G proteins lead to desensitization. Familiar examples include desensitization to light, odors and chemical stimulants such as caffeine.
Receptors, G proteins, and effector MAP kinases are conserved in evolution and are even found in the simplest eukaryotes such as yeast. Through large-scale genomics, proteomics and metabolomics analysis the lab has identified new mutants with altered signaling and desensitization properties. These are then characterized biochemically and biophysically using homologous proteins in humans. This approach led to the identification in yeast of a family of desensitization factors called RGS proteins (Regulator of G protein signaling). Whereas GPCRs activate G proteins, RGS proteins inactivate G proteins, by accelerating their GTPase activity.
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Journal of Biological Chemistryno. 3 (2024)
The Journal of biological chemistryno. 5 (2023): 104617-104617
Kevin M. Knight, Elizabeth G. Obarow,Wenyuan Wei, Sepehr Mani, Maria I. Esteller,Meng Cui,Ning Ma, Sarah A. Martin, Emily Brinson,Natalie Hewitt, Gaby M. Soden,Diomedes E. Logothetis,
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