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个人简介
Personalised Therapeutics
Drug treatment is the cornerstone of today’s medicine. In this respect, pharmacology is a key driver for the advancement of health care and thus essential for patient’s well-being. However, the outcome of drug treatment is highly variable. Indeed, everyday large numbers of patients receive medications that are, at an individual level, either ineffective or harmful. Therefore, to successfully treat individual patients a personalised therapeutics approach is needed. Genetics has emerged as an important source of variability in drug response and genetic biomarkers are increasingly incorporated in drug and dose selection.
It is our goal to optimize drug treatment of the patient by personalising the dose and drug selection based on a better understanding of the genetic variation that is causal for the inter-patient variability in drug response. We also aim to develop models that include genetic and non-genetic markers that can be readily implemented in daily clinical practice. To achieve these research ambitions we have formed a group of experts that covers the required fields within the area of clinical pharmacology, pharmacogenomics, human genetics, pharmacokinetics, pharmacodynamics, pharmacometrics, bio-informatics and bio-analytics. This combination of expertise allows the successful identification of genetic biomarkers for drug response while the clinical environment enables prompt translation to patient care.
Our research is centred on three main themes:
Discovery of pharmacogenomic biomarkers in cancer
Implementation of pharmacogenomics in clinical practice
Development of personalised drug treatments
Position in international context
The department is internationally leading in the field of personalised therapeutics, and has a well-recognized expertise and track-record in the fields of cancer pharmacogenomics and clinical implementation of personalised therapeutics. This is reflected in the large number of invitations to present our scientific progress on conferences (ASCPT, PGRN, ISSX, EACPT, G2MC, KNMP, IMC), to serve as reviewer (CPT, JCO, CCR, Ann Intern Med) or editorial board member (Pharmacogenomics, Pharmacogenetics Genomics, EJCP), to serve as grant reviewer for international funding organizations (US, Canada, Austria, France, Norway, UK, NL), to serve as members of guideline committees (DPWG, CPIC), and conference programme committees (PGRN, ASCPT, NIH, KNMP). The department has acquired several prestigious international and national grants including a HORIZON2020 grant “Ubiquitous Pharmacogenomics” (coordinator role, €15.000.000), and KWF Alpe d’huez grant “DPD pharmacogenomics” (PI role, €1,200.000).
Our research group has a very strong position in Europe as is shown by the coordinating role of a large consortium funded by the EU (U-PGx). We are the founding father of the Leiden Network for Personalised Therapeutics, a collaborative network with the mission to coalesce and align academic and patient-oriented research activities in personalised therapeutics. In addition, the development of Personalised Drug Treatments is embedded in the Leiden university research profile Translational Drug Discovery and Development which is co-chaired by our group leader.
研究兴趣
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Clinical pharmacology and therapeuticsno. 1 (2024): 155-164
Respiratory medicinepp.107723-107723, (2024)
CLINICAL PHARMACOLOGY & THERAPEUTICSno. 6 (2024): 1282-1292
CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGYno. 4 (2024): 612-623
EUROPEAN JOURNAL OF HUMAN GENETICSno. 2 (2024): 155-162
Sumudu Rangika Samarasinghe,Seung-Been Lee,Manuel Corpas,Segun Fatumo,Henk-Jan Guchelaar,Shivashankar H Nagaraj
Clinical pharmacology and therapeutics (2024)
EUROPEAN JOURNAL OF HUMAN GENETICSpp.1-9, (2024)
Claire D Visser, Lisanne L M Antonisse, Floor M Alleda, Colin Bos,Privender Saini,Esther Kuipers,Henk-Jan Guchelaar,Martina Teichert
British journal of clinical pharmacologyno. 5 (2024): 1344-1356
Anna M. McLaughlin,Thomas Helland, Fenja Klima,Stijn L. W. Koolen,Ron H. N. van Schaik,Ron H. J. Mathijssen,Patrick Neven,Jesse J. Swen,Henk-Jan Guchelaar,Florence Dalenc,Melanie White-Koning,Robin Michelet,
CLINICAL PHARMACOLOGY & THERAPEUTICS (2024)
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