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个人简介
Helen Saibil is a molecular biologist who uses three-dimensional electron microscopy to examine the cellular machines that carry out the functions of life. Her work has resulted in the remarkable visualisation of both molecular chaperones — proteins that help other macromolecules fold and unfold — and the misfolding of proteins that form fibrils implicated in amyloid disease.
Her most recent studies have investigated the operation of perforin, a protein ‘weapon’ used by the immune system to punch holes in cancerous or infected cells, through which destructive enzymes can subsequently travel. These findings stem from Helen’s previous research on a similar pore-forming bacterial toxin.
In addition to being a Fellow of the Society, Helen is a Fellow of the Academy of Medical Sciences, an Honorary Member of the British Biophysical Society and an Honorary Fellow of the Royal Microscopical Society. She has also received a number of awards for her work, including a five-year programme grant from the Wellcome Trust in 2009.
研究兴趣
论文共 203 篇作者统计合作学者相似作者
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crossref(2024)
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Proceedings of the National Academy of Sciences of the United States of Americano. 50 (2023): e2308933120-e2308933120
Guendalina Marini,Brad Poland,Chris Leininger,Natalya Lukoyanova, Dan Spielbauer,Jennifer K. Barry,Dan Altier,Amy Lum,Eric Scolaro,Claudia Pérez Ortega,Nasser Yalpani, Gary Sandahl,
Nature Communicationsno. 1 (2023): 1-11
Natalie Al-Otaibi,Pieter Baatsen,David Bhella, Rosaria Brescia,Per Bullough,Bertram Daum, Reinier de Bruin,Rene Frank,Werner Kuhlbrandt,Carmen Lopez-Iglesias,Mathew McLaren,Rebbekah Menday,
FARADAY DISCUSSIONSno. 0 (2022): 142-151
Saskia E. Bakker,Julien Bergeron,Alok Bharadwaj,David Bhella,Per Bullough, Pak-Lee Chau,Rene A. W. Frank,Arjen J. Jakobi,Agnel Praveen Joseph,Werner Kuhlbrandt, Indrajit Lahiri,Rebbekah Menday,
FARADAY DISCUSSIONS (2022): 229-242
G. Marini,B. Poland, C. Leininger,N. Lukoyanova, D. Spielbauer,J. Barry,D. Altier,A. Lum,E. Scolaro,C. Pérez Ortega, N. Yalpani, G. Sandahl,
Saskia E Bakker,David Bhella, Rosaria Brescia,Per Bullough,Daniel K Clare,Bertram Daum,René A W Frank,Vicki A M Gold, Isobel Jackson Hirst,Werner Kühlbrandt,Penghan Lu,Mathew McLaren,
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