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Bio
Our main goal is to improve immunotherapy for cancer patients by using translational in vitro and in vivo tumor models, performing correlative analysis of patients treated with immunotherapy and conducting early clinical interventional trials (also see link to Medical Oncology).
One of our research focus is on the role of glycans and glycan-binding receptors in anti-cancer immunity. Glycans can mediate important interactions with immune cells and manipulation of glycans and glycan-binding receptors (lectins) bear a great potential to improve anti-tumor immune reactions. Glycan-mediated interactions in cancer immunology are significantly underexplored and could be used to improve anti-cancer immunity. Our group has studied the interaction between glycans that contain sialic acids (siaologlycans) and their interaction with Siglec receptors on immune cells and have demonstrated that this pathway can be targeted to augment T cell stimulation and tumor control. Current goals include improvement of cancer immunotherapy by modifying glycans in the tumor microenvironment and glycans of cellular products for adoptive cell therapies including genetically modified T cells.
An additional focus of our group is the improvement of immune checkpoint blockade and adoptive cellular therapies by investigating mechanisms and patterns of resistance to these therapies. To this end, we are investigating the tumor microenvironment as well as circulating immune cells in patients undergoing immune checkpoint blockade or adoptive T cell transfer. Identified pathways are further studied in the laboratory for their potential as new targets to improve antitumor immune responses.
One of our research focus is on the role of glycans and glycan-binding receptors in anti-cancer immunity. Glycans can mediate important interactions with immune cells and manipulation of glycans and glycan-binding receptors (lectins) bear a great potential to improve anti-tumor immune reactions. Glycan-mediated interactions in cancer immunology are significantly underexplored and could be used to improve anti-cancer immunity. Our group has studied the interaction between glycans that contain sialic acids (siaologlycans) and their interaction with Siglec receptors on immune cells and have demonstrated that this pathway can be targeted to augment T cell stimulation and tumor control. Current goals include improvement of cancer immunotherapy by modifying glycans in the tumor microenvironment and glycans of cellular products for adoptive cell therapies including genetically modified T cells.
An additional focus of our group is the improvement of immune checkpoint blockade and adoptive cellular therapies by investigating mechanisms and patterns of resistance to these therapies. To this end, we are investigating the tumor microenvironment as well as circulating immune cells in patients undergoing immune checkpoint blockade or adoptive T cell transfer. Identified pathways are further studied in the laboratory for their potential as new targets to improve antitumor immune responses.
Research Interests
Papers共 146 篇Author StatisticsCo-AuthorSimilar Experts
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JOURNAL FOR IMMUNOTHERAPY OF CANCERno. 1 (2024)
BMC Cancerno. 1 (2024): 1-7
crossref(2024)
Filip Filipsky,Heinz Läubli
Florian Maerkl,Christoph Schultheiss, Murtaza Ali,Shih-Shih Chen,Marina Zintchenko,Lukas Egli,Juliane Mietz,Obinna Chijioke,Lisa Paschold, Sebastijan Spajic,Anne Holtermann,Janina Doerr,
Ronja Wieboldt, Michael Sandholzer,Emanuele Carlini,Chia-wei Lin,Anastasiya Börsch,Andreas Zingg,Didier Lardinois,Petra Herzig, Leyla Don,Alfred Zippelius,Heinz Läubli,Natalia Rodrigues Mantuano
Immuno-Oncology and Technologyno. 5 (2024): 1-15
Ignacio Melero, María de Miguel Luken,Guillermo de Velasco,Elena Garralda,Juan Martin Liberal,Markus Joerger,Guzman Alonso, Maria-Elizabeth Goebeler,Martin Schuler,David König,Reinhard Dummer, Mara Reig,
crossref(2024)
American journal of respiratory and critical care medicine (2024)
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAno. 9 (2024): e2400499121-e2400499121
David König, Michael T Sandholzer,Sarp Uzun,Andreas Zingg,Reto Ritschard, Helen Thut,Katharina Glatz,Elisabeth A Kappos,Dirk J Schaefer,Christoph Kettelhack,Jakob R Passweg,Andreas Holbro,
Cancer immunology researchno. 7 (2024): 814-821
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Author Statistics
#Papers: 147
#Citation: 4710
H-Index: 32
G-Index: 68
Sociability: 7
Diversity: 3
Activity: 109
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