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Bio
I have over 20 years of independent research experience in the areas of lipoprotein metabolism, atherosclerosis, and vascular biology. Over the years, I have studied the key early events in atherogenesis, including monocyte:endothelial interactions and macrophage foam cell formation in atherosclerosis. We have discovered that an orphan nuclear receptor, NR4A1, regulates monocyte development from bone marrow progenitors and is critical for the production of a patrolling monocyte that is involved in the resolution of inflammation. We now are interested in how Nr4a1 is regulated in monocyte progenitors to control monocyte development. We are quite interested in the functions of patrolling monocytes in vivo. We have found that these monocytes are involved in homeostatic patrolling of the vasculature, and we hypothesize that they are important in clearing the vasculature of damaged endothelium and foreign pathogens, oxidized lipids, or tumor cells. We are interested in their functions in the context of chronic inflammatory disease, such as atherosclerosis and cancer.
Research Interests
Papers共 281 篇Author StatisticsCo-AuthorSimilar Experts
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Leila Akkari,Ido Amit,Vincenzo Bronte, Zvi G. Fridlender,Dmitry I. Gabrilovich, Florent Ginhoux,Catherine C. Hedrick,Suzanne Ostrand-Rosenberg
Nature Reviews Immunologypp.1-8, (2024)
Omar M. Makram, Harikrishnan Hyma Kunhiraman,Ryan A. Harris,Catherine C. Hedrick,Khurram Nasir,Neal L. Weintraub,Xiaoling Wang,Avirup Guha
American Heart Journal Plus: Cardiology Research and Practice (2024): 100380-100380
Cancer Researchno. 6_Supplement (2024): 2689-2689
Leila Akkari,Ido Amit,Vincenzo Bronte, Zvi G Fridlender,Dmitry I Gabrilovich, Florent Ginhoux,Catherine C Hedrick,Suzanne Ostrand-Rosenberg
Nature reviews. Immunology (2024)
Cancer Researchno. 6_Supplement (2024): 2679-2679
Nandini Chatterjee, Ravi K. Komaravolu,Christopher P. Durant,Runpei Wu,Chantel Mcskimming,Fabrizio Drago,Sunil Kumar, Gabriel Valentin-Guillama,Yury I. Miller,Coleen A. Mcnamara,Klaus Ley,Angela Taylor,
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCESno. 5 (2024): 2894
Cancer Researchno. 6_Supplement (2024): 2459-2459
Cancer cellno. 1 (2023): 35-51.e8
Cancer Researchno. 7_Supplement (2023): 2142-2142
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