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个人简介
Research interests
The main focus of my lab is mitochondria in neurodegenerative diseases, primarily focused on Parkinson’s Disease. This encompasses mitochondrial function, DNA, morphology and recycling as well as links with other cellular pathways.
My research focuses on both trying to further the understanding of the causes of mitochondrial problems in neurodegenerative conditions and in vitro drug screening for molecules which rescue mitochondrial function in patient tissue.
The lab has also recently become interested in investigating these mitochondrial abnormalities in Alzheimer’s Disease and Motor Neuron Disease patient derived cells. It is interesting to investigate the differing mitochondrial phenotypes between neurodegenerative diseases and the mechanisms by which they occur and potentially drive neuronal vulnerability.
研究兴趣
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crossref(2024)
Calum Harvey, Marcel Weinreich, James A. K. Lee,Allan C. Shaw,Laura Ferraiuolo,Heather Mortiboys,Sai Zhang,Paul J. Hop,Ramona A. J. Zwamborn,Kristel van Eijk,Thomas H. Julian,Tobias Moll,
HELIYONno. 3 (2024): e24975-e24975
Zengjie Xia,Emily E. Prescott,Agnieszka Urbanek, Hollie E. Wareing, Marianne C. King, Anna Olerinyova,Helen Dakin, Tom Leah,Katy A. Barnes,Martyna M. Matuszyk,Eleni Dimou, Eric Hidari,
NATURE COMMUNICATIONSno. 1 (2024): 4695-4695
AGING CELLno. 3 (2024)
International review of neurobiology (2024): 269-325
Wing Hei Au,Leonor Miller-Fleming,Alvaro Sanchez-Martinez, James Ak Lee,Madeleine J Twyning,Hiran A Prag, Laura Raik,Scott P Allen,Pamela J Shaw,Laura Ferraiuolo,Heather Mortiboys,Alexander J Whitworth
Life science allianceno. 9 (2024)
Biochemical Journalno. 4 (2024): 265-278
Journal of Parkinson's diseaseno. 6 (2023): 853-866
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