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The Murray Lab studies bacterial DNA replication initiation in the model organism Bacillus subtilis. Using a combination of genetics, cell biology, molecular biology, and biochemistry, we are investigating the structure of the bacterial chromosome origin and the activity of replication initiation proteins required to unwind the DNA duplex and to load the replicative helicases. One of the key tools we have developed is an inducible artificial chromosome origin that allows us to bypass normally essential endogenous replication initiation factors. We are keen to explore the utility of more sophisticated synthetic replication systems, both for fundamental understanding of DNA replication and for exploitation in biotechnology. We are also utilizing our expertise to search for novel antibiotics that target DNA replication proteins.
研究兴趣
论文共 84 篇作者统计合作学者相似作者
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NEW GENETICS AND SOCIETYno. 1 (2023)
Nucleic acids researchno. 9 (2023): 4322-4340
Simone Pelliciari, Salomé Bodet-Lefèvre,Stepan Fenyk,Daniel Stevens,Charles Winterhalter,Frederic D Schramm,Sara Pintar,Daniel R Burnham,George Merces,Tomas T Richardson, Yumiko Tashiro, Julia Hubbard,
Nature communicationsno. 1 (2023): 8339-8339
Access Microbiologyno. 5 (2022)
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature (2022)
bioRxiv (Cold Spring Harbor Laboratory) (2022)
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