基本信息
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The main focus of the Clinical Neurochemistry working group is the understanding of the pathological processes that underly neuroinflammatory and neurodegenerative disorders, as well as their (early) diagnosis and monitoring using fluid biomarkers. For that purpose, we identify and evaluate biomarker candidates and establish novel biomarker assays for the detection of proteins in cerebrospinal fluid (CSF) and blood, applying highly sensitive state-of-the-art immunoassay methods e.g., single-molecule array (Simoa) or microfluidic systems (ELLA). We aim to thoroughly evaluate and validate potential new biomarker assays, both regarding their relevance as diagnostic, prognostic, or progression markers in inflammatory and neurodegenerative diseases, as well as regarding the applicability and validity of the assay itself for the use in clinical routine. In addition to assay development, we conduct single- and multicenter studies using existing or novel biomarker assays. These studies aim to investigate correlations between biomarkers and clinical evaluations to learn more about how these markers could be effectively implemented into daily clinical practice. As a translational working group our ultimate objective is to successfully transfer these biomarkers into clinical routine, allowing patients to benefit from improved diagnostic accuracy and enabling personalized patient care.
Research Interests
Papers共 349 篇Author StatisticsCo-AuthorSimilar Experts
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引用量
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期刊级别
合作者
合作机构
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCESno. 1 (2024): 425
NATURE REVIEWS NEUROLOGYno. 5 (2024): 269-287
CLINICAL CHEMISTRY AND LABORATORY MEDICINEno. 8 (2024): 1591-1601
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRYno. 5 (2024): 410-418
EClinicalMedicine (2024): 102495
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Neurological Research and Practiceno. 1 (2024): 1-10
Brain : a journal of neurology (2024)
Neurology(R) neuroimmunology & neuroinflammationno. 4 (2024): e200270-e200270
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Author Statistics
#Papers: 351
#Citation: 11686
H-Index: 61
G-Index: 97
Sociability: 8
Diversity: 3
Activity: 118
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