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个人简介
I have extensive experience in cancer biology, cell biology, immunology, signal transduction and in vivo mice models for cancer pathophysiology. I have more than 30 years of experience in the basic science and translational research in the field of oncology, resulting in more than 140 peered reviewed publications/articles.
My current expertise is in the area of breast cancer progression, signaling pathways, cancer metastasis, and vascular biology, with the focus on the molecular mechanisms for cancer progression and breast metastasis development in the brain. My research interests are: 1.The identification of cancer drivers responsible for breast and ovarian cancer growth originated from the tumor cells and the tumor niches; 2. The neurovascular unit (NVU) functions and brain microvascular endothelial cells (BMECs) and their modulation by triple negative breast cancer cells (TNBCs), following TNBC extravasation to the brain; and 3. Discovery and characterization of lipid based approaches for targeted therapy in breast cancer such as specific inhibitors for monoacylglycerol lipase (MGL) and N-acylethanolamine acid amidase (NAAA).
The major goals of my early career had been to conduct basic research to identify novel genes and pathways regulating hematopoiesis and cancer. During the past 25 years in Harvard Medical School and Beth Israel Deaconess Medical Center (Boston) and at Northeastern University (Boston), my research is in the area of signaling mechanisms that are essential for normal tissue growth and development, but are perturbed in cancer. Specifically, my lab has focused on signaling pathways of tyrosine kinases, such as CSK, CHK, SRC, FAK, RAFTK/Pyk2, ErbB-2 and VEGF receptors in breast cancer cells and the identification of molecular mechanisms important in breast cancer tumorigenesis and breast cancer metastasis to the brain.
研究兴趣
论文共 160 篇作者统计合作学者相似作者
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Seyha Seng,Hava Karsenty Avraham,Shuxian Jiang, Suping Yang,Masayuki Sekine, Noam Kimelman, Huchun Li,Shalom Avraham
crossref(2023)
Oncogeneno. 29 (2023): 1-1
Seyha Seng,Hava Karsenty Avraham,Shuxian Jiang, Suping Yang,Masayuki Sekine, Noam Kimelman, Huchun Li,Shalom Avraham
crossref(2023)
Research Square (Research Square) (2021)
Breast Cancer Metastasis and Drug Resistancepp.211-226, (2013)
S. Jiang,M. Alberich-Jorda,R. Zagozdzon, K. Parmar,Y. Fu,P. Mauch, N. Banu,A. Makriyannis, D. G. Tenen,S. Avraham, J. E. Groopman,H. K. Avraham
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