基本信息
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个人简介
The research efforts in the Sabaawy laboratory is focused on studying normal stem cell development and cancer stem cells utilizing patient-derived cells, genome sequencing, tumor initiation models, 3D stem cell derived organoid cultures and humanized mouse models and xenografts for drug discovery. These studies aim to dissect normal stem cell developmental pathways, and how cancer stem cells divert from these regulatory pathways. One major pathway for research focus in the laboratory is the regulation of stem cell self-renewal by the polycomb gene BMI1 and cyclin dependent kinase inhibitors p15 (CDKN2b) and p16 (CDKN2a) regulating the cell cycle and senescence. Utilizing novel organoid cultures, CRISPR- and recombinase-mediated genome editing and drug modifiers together with transgenic and xenograft approaches; the laboratory is generating models for precision therapy of several cancers such as prostate cancer, glioblastomas and leukemias.
研究兴趣
论文共 70 篇作者统计合作学者相似作者
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Liqiong Liu, Ann Strange, Schuyler Lee,Bifeng Gao,Daniel Merrick,Tejas Patil,James DeGregori,D Ross Camidge,Sharon R. Pine,Hatim E. Sabaawy
Cancer Researchno. 6_Supplement (2024): 6496-6496
Journal of Thoracic Oncologyno. 11 (2023): S87-S87
JOURNAL OF THORACIC ONCOLOGYno. 11 (2023): S87-S87
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Frontiers in oncology (2023): 1243534
Frontiers research topics (2023)
Oncogeneno. 27 (2023): 2183-2194
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作者统计
#Papers: 69
#Citation: 1283
H-Index: 20
G-Index: 35
Sociability: 6
Diversity: 3
Activity: 29
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