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Harry Lewis Malech
Senior Investigator
Laboratory of Clinical Immunology & Microbiology
National Institute of Allergy and Infectious Diseases, National Institutes of Health;Genetic Immunotherapy Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health
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基本信息
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个人简介
Dr. Malech’s research and clinical program within LCIM is the GIS. The mission of GIS is the development of gene therapy and hematopoietic stem cell transplantation approaches to the treatment of a variety of inherited primary immune deficiencies. Associated with that mission is the diagnosis and treatment of the infections, inflammation, autoimmunity, pulmonary dysfunction, and growth failure that may complicate management of a number of primary immune deficiencies.
Major Areas of Research
Clinical trials and basic research of gene therapy using ex vivo transduction of autologous CD34+ hematopoietic stem cells
Allogeneic transplantation using hematopoietic stem cell grafts
Chronic granulomatous disease
X-linked severe combined immune deficiency
Other forms of severe combined immune deficiency
Acute and chronic graft versus host disease
Biology of engraftment of hematopoietic stem cells and the role of the CXCR4 chemokine receptor
Excessive inflammation and associated autoimmune symptoms with primary immune deficiencies (PIDs)
Induced pluripotent stem cells used to model human immune deficiencies and for development of novel treatments
研究兴趣
论文共 589 篇作者统计合作学者相似作者
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Maria Carmina Castiello,Chiara Brandas,Samuele Ferrari,Simona Porcellini, Nicolò Sacchetti,Daniele Canarutto,Elena Draghici,Ivan Merelli,Matteo Barcella, Gabriele Pelosi,Valentina Vavassori,Angelica Varesi,
Science translational medicineno. 733 (2024): eadh8162-eadh8162
Bloodno. 1 (2023): 23-32
Transplantation and Cellular Therapyno. 2 (2023): S62-S63
JOURNAL OF CLINICAL IMMUNOLOGYno. 8 (2023): 1964-1973
Quentin Riller,Jacques Fourgeaud, Julie Bruneau,Suk See De Ravin,Grace Smith,Mathieu Fusaro, Samy Meriem,Aude Magerus,Marine Luka, Ghaith Abdessalem,Ludovic Lhermitte,Anne Jamet,
Cellno. 7 (2023): 1302-1304
Sumona Bhattacharya,Uni Wong, Mian Khalid,Hanna Blaney, Matthew G Menkart, Jenna L Oringher,Sonia L Taneja,Christa S Zerbe,Suk See De Ravin,Harry L Malech,Steven M Holland,Christopher Koh,
Journal of gastroenterology and hepatologyno. 12 (2023): 2083-2089
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