Harish C. Pant

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His laboratory is studying the mechanisms of topographic regulation of neuronal cytoskeleton proteins by post-translational modification, including the role of kinase cascades in normal brain and during neurodegeneration.

Research Interests

Papers共 293 篇Author StatisticsCo-AuthorSimilar Experts

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Investigation of the Effect of Peptide P5 Targeting CDK5-p25 Hyperactivity on Munc18-1 (P67) Regulating Neuronal Exocytosis Using Molecular Simulations

Tejaswi Tammareddy,Walid Keyrouz,Ram D. Sriram,Harish C. Pant,Antonio Cardone,Jeffery B. Klauda

Biochemistry（2024）

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Insights into the Selective Inhibition of an Alzheimer’s Disease Drug Candidate P5 on CDK5-p25 Complex in the Presence of Munc18-1 Using Umbrella Sampling Molecular Simulations

Tejaswi Tammareddy,Antonio Cardone,Harish C. Pant,Walid Keyrouz,Ram Sriram,Jeffery B. Klauda

Biophysical Journalno. 3 (2024): 416a-416a

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Investigation of the Potential Off-Target Effects on Munc 18 (p67) Involved in Synaptic Vesical Transport Due to the Interaction with Peptide P5

Tejaswi Tammareddy,Antonio Cardone,Harish C. Pant,Walid Keyrouz,Ram Sriram,Jeffery B. Klauda

Biophysical Journal（2023）

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TP5: A Novel Therapeutic Approach Targeting Aberrant and Hyperactive CDK5/p25 for the Treatment of Colorectal Carcinoma

Niranjana Amin,Herui Wang,Qi Song,Manju Bhaskar,Sharda Prasad Yadav,Mark R. Gilbert,Harish Pant,Emeline Tabouret,Zhengping Zhuang

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES（2023）

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Cyclin-Dependent Kinase 5 Regulates Cpla2 Activity and Neuroinflammation in Parkinson’s Disease

Sangita Paul,Saman Fatihi,Srishti Sharma,Rintu Kutum, Raymond Fields,Harish C. Pant,Lipi Thukral,B. K. Binukumar

eNeuro（2022）

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Computational Study of the Allosteric Effects of P5 on CDK5-p25 Hyperactivity As Alternative Inhibitory Mechanisms in Neurodegeneration

Tejaswi Tammareddy,Walid Keyrouz,Ram D. Sriram,Harish C. Pant,Antonio Cardone,Jeffery B. Klauda

The Journal of Physical Chemistry B（2022）

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Inhibition of hyperactive cyclin dependent kinase 5/p25 is protective in the 6-hydroxydopamine model of Parkinson’s disease

Ashley Bernardo,Niranjana Amin,BK Binukumar,Harish Pant,Ram Mishra

biorxiv（2022）

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In Silico Study on the Selective Inhibition of Alzheimer's Disease (AD) Pathological Complex Cdk5-P25 by Peptide P5 in Presence of Munc 18 (P67)

Tejaswi Tammareddy,Antonio Cardone,Sergio A. Hassan,Harish C. Pant,Mary Brady,Walid Keyrouz,Ram Sriram,Jeffery B. Klauda

BIOPHYSICAL JOURNAL（2022）

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CSIG-24. TARGETED INHIBITION OF CDK5-MEDIATED REGULATION OF HUMAN ENDOGENOUS RETROVIRUS K (HML-2) ENVELOPE PROTEIN IN ATYPICAL TERATOID RHABDOID TUMOR

Tara Doucet-O'Hare,Jared Rosenblum,Brianna DiSanza,Catherine DeMarino,Abigail Atkinson,Nasir Malik,Joe Steiner,Harish Pant,Avindra Nath,Zhengping Zhuang

NEURO-ONCOLOGY（2021）

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Investigation of Allosteric Inhibition Mechanisms by the Peptide P5 on the Alzheimer's Disease (AD) Pathological Complex Cdk5-P25 Through Molecular Dynamics Simulations

Tejaswi Tammareddy,Antonio Cardone,Sergio Hassan,Harish C. Pant,Mary Brady,Walid Keyrouz,Ram Sriram,Jeffery B. Klauda

Biophysical Journal（2021）

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Papers共 293 篇Author StatisticsCo-AuthorSimilar Experts