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职业迁徙
个人简介
Among his major achievements is the identification of distinct biological roles of Protein Kinase C. He was the first to show that Protein Kinase C isoforms display highly divergent biological properties, and he described these in differentiation and oncogenic transformation (Mischak et al. 1993, J Biol Chem 268, 1749-1756 and 20110-20115) and associated these with distinct intracellular localization (Goodnight, Mischak, et al. 1995, J Biol Chem 270:9991-10001). Together with Walter Kolch (for Raf signaling, e.g. Kolch et al. 1993, Nature 364:249-252) and Hans Hacker (for CpG signaling, e.g. Hacker, Mischak et al. 1998, EMBO J 17:6230-6240) he pinpointed the role of kinases in several major signaling mechanisms. All of these manuscripts have been cited several hundred times. Based on his experience on proteomics in basic research, he initiated the use of urinary proteomics and capillary electrophoresis coupled mass spectrometry for clinical application, and is the leading authority in clinical proteomics and biomarker identification. Among his achievement in this field are the development of guidelines for clinical proteome analysis, where he led a large international and multidisciplinary group to develop clinically relevant proteomic biomarkers (Mischak et al. 2007, Proteomics Clin Appl 1:148-156; 2010, Sci Transl Med 2:46ps42; 2012, Eur. J Clin Invest 42, 1027-1036), and the demonstration of successful application in the diagnosis and prognosis of several diseases (e.g. Decramer et al. 2006, Nat. Med. 12:398-400; Theodorescu et al. 2006, Lancet Oncol. 7:230-240; Rossing et al. 2008, JASN 19:1283-1290; Good et al. 2010, Molecular & Cellular Proteomics 9:2424-2437; Kuznetsova et al. 2012, Eur. Heart J. 33, 2342-2350).
研究兴趣
论文共 773 篇作者统计合作学者相似作者
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Teresa Frattini, Hanne Devos,Manousos Makridakis,Maria Roubelakis,Antonia Vlahou,Agnieszka Latosinska,Harald Mischak, Joost P. Schanstra, Jean Sébastien Saulnier-Blache
crossref(2024)
International journal of molecular sciencesno. 7 (2024): 3678
Maire Brasseler,Harald Mischak,Joost P. Schanstra, Juliane Marie Michel,Lars Pape,Ursula Felderhoff-Mueser
NEONATOLOGYpp.1-9, (2024)
Maria Frantzi, Ana Christina Morillo, Guillermo Lendinez, Ana Blanca-Pedregosa,Daniel Lopez Ruiz, Jose Parada,Isabel Maria Heidegger,Zoran Culig,Emmanouil Mavrogeorgis, Antonio Lopez Beltran, Marina Mora-Ortiz, Julia Carrasco-Valiente,
medrxiv(2024)
Hypertension (Dallas, Tex. : 1979) (2024)
International journal of molecular sciencesno. 6 (2024): 3519
Ioanna K. Mina,Emmanouil Mavrogeorgis,Justyna Siwy, Riste Stojanov,Harald Mischak,Agnieszka Latosinska,Vera Jankowski
PROTEOMICSno. 5 (2024): e2300227-e2300227
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