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Chitin is one of the most abundant organic compounds on earth and becomes increasingly important as a renewable resource for the chemical/pharmaceutical industry. To obtain more insight into the process of chitin synthesis, we investigate the expression and regulation of the involved genes, analyze the functions of the derived proteins and dissect the reactions in which they participate. To allow comparative analyses and different experimental strategies, we address these questions in different insect model organisms (Aedes aegypti, Manduca sexta, Tribolium castaneum), which are amenable to RNA interference allowing analysis of gene function. We use also the genetic model system Saccharomyces cerevisiae, because it allows us to analyze the intracellular maturation and trafficking of the proteins involved in chitin synthesis, and transfer the results to insect cells.
The examined proteins including chitin synthases, chitin modifying enzymes, chitin organizing proteins and certain endopeptidases involved in molting are promising target sites for the action of novel environmentally safe insecticides and miticites. Actually, several classes of commercially used insecticides and miticites such as benzoylureas and diphenyloxazolines act as chitin synthesis inhibitors. Their mode of action, pharmacology, toxicology and resistance mechanisms are matters of particular interest to us and we address these questions using biochemical, genomic and proteomic tools.
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INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY (2024): 104058-104058
Anton G. Windfelder, Frank H. H. Mueller,Benedict Mc Larney,Michael Hentschel,Anna Christina Boehringer, Christoph-Ruediger von Bredow,Florian H. Leinberger,Marian Kampschulte,Lorenz Maier,Yvette M. von Bredow,Vera Flocke,Hans Merzendorfer,
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY (2023): 105026-105026
Journal of Integrative Agricultureno. 5 (2023): 1618-1633
Insect biochemistry and molecular biology (2023): 104029-104029
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