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个人简介
Dr. Hanmeng Zhang obtained her Ph.D. in Cell Biology, Neurobiology & Anatomy from the Medical College of Wisconsin (MCW) in Milwaukee, WI. Under the guidance of her advisor, Daniel M. Lipinski, MSc., DPhil., she conducted research on gene therapy treatments for rare ocular diseases in mice and AAV-mediated modeling of cone dystrophy in the 13-Lined Ground Squirrel. Prior to her doctoral studies, Dr. Zhang earned a Bachelor of Kinesiology from Beijing Sport University (BSU) in Beijing, China, where she focused on aerobic exercise-induced inhibition of the PKCα pathway and its effects on the vasodilation of mesenteric arteries in a rat model of hypertension.
Between her Bachelor's and doctoral studies, Dr. Zhang worked as a Research Assistant in Dr. Margarete Wong-Riley's Lab at the Department of Cell Biology, Neurobiology & Anatomy, also at MCW, from October 2014 to May 2016. During her time there, she monitored spontaneous excitatory and inhibitory postsynaptic currents in the visual cortex of wildtype Sprague-Dawley rat pups. Her work aimed to evaluate the contribution of brain-derived neurotrophic factor to the excitatory-inhibitory imbalance during the critical period of postnatal respiratory and visual development in rats. This experience further deepened her understanding of neuroscience and nurtured her passion for vision biology.
Currently, as a research fellow since February 2022, Dr. Zhang is having her postdoctoral training at the Ocular Genomic Institute of Mass. Eye and Ear and the Department of Ophthalmology at Harvard Medical School in Boston, MA. Her research is focused on unraveling the mechanisms underlying inherited retinal diseases. In particular, she is exploring the impact of NMNAT1 gene mutations on retinal degeneration. Leveraging advanced techniques such as single-cell RNA sequencing, Dr. Zhang aims to gain insights into the intricate gene expression patterns and molecular mechanisms that contribute to photoreceptor degeneration. Additionally, her work encompasses the characterization of induced pluripotent stem cells (IPSCs) and IPSC-derived retinal organoids. By utilizing different differentiation protocols, she aims to understand how IPSCs and retinal organoids can be harnessed for disease modeling and potential therapeutic applications.
研究兴趣
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#Papers: 11
#Citation: 44
H-Index: 3
G-Index: 6
Sociability: 3
Diversity: 0
Activity: 0
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