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Bio
My major research interests focus on behavioral and cellular signaling mechanisms in treatment of neurodegenerative and neuropsychiatric disorders.Specifically, I am interested in exploring the roles of cyclic nucleotide (cAMP/cGMP) signaling in the mediation of depression, anxiety, alcohol dependence, drug abuse, and memory loss associated with neurodegenerative disorders such as Alzheimer’s disease. Techniques include various animal behavioral tests (e.g., radial arm-maze, water-maze, passive avoidance, and object recognition for memory; DRL schedule, forced-swim, and tail-suspension for depression; elevated-plus maze, holeboard, and light-dark transition for anxiety; alcohol drinking behavior, self-administration, and righting reflex for alcohol and/or drug dependence), small animal surgeries for brain microinfusions, enzyme assays, immunoblotting, immunohistochemistry, RNAi gene silencing (shRNAs, CRISPR-Cas9), optogenetics, etc. Our goals are to develop ideal treatments for neurodegenerative and neuropsychiatric disorders, drug abuse and dependence and elucidate the mechanisms whereby intracellular signaling mediates these disorders.
Research Interests
Papers共 88 篇Author StatisticsCo-AuthorSimilar Experts
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Fang-Fang Zhang,Hao Wang,Yan-Meng Zhou, Hai-Yang Yu,Melanie Zhang, Xian Du,Dong Wang,Feng Zhang,Ying Xu,Ji-Guo Zhang,Han-Ting Zhang
Neuropharmacology (2021): 108694-108694
Hao Wang,Fang-Fang Zhang,Yong Xu, Hua-Rong Fu, Xiao- Dan Wan,Lei Wang,Wei Chen,Xiao-Yan Xu,Yong-Feng Gao,Ji-Guo Zhang,Han-Ting Zhang
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Author Statistics
#Papers: 107
#Citation: 4398
H-Index: 36
G-Index: 64
Sociability: 6
Diversity: 0
Activity: 1
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