基本信息
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职业迁徙
个人简介
RESEARCH SUMMARY
Howard Young has expertise in the regulation and characterization of cytokine gene expression with a special emphasis on interferons. The Young laboratory has as its major focus how disruption of the control of interferon-γ (IFN-γ) gene expression during development and maturation of the cellular immune system impacts the host inflammatory response and the development of autoimmune disease and cancer. His laboratory has developed a mouse model of chronic Interferon-gamma expression that results in at least 3 different autoimmune diseases resembling lupus, ovarian failure syndrome and primary biliary cholangitis. In addition the male mice exhibit a heart function defect after exercise, This model may provide new insight into the initiation and progression of these diseases and offer novel approaches to treatment.
Howard Young has expertise in the regulation and characterization of cytokine gene expression with a special emphasis on interferons. The Young laboratory has as its major focus how disruption of the control of interferon-γ (IFN-γ) gene expression during development and maturation of the cellular immune system impacts the host inflammatory response and the development of autoimmune disease and cancer. His laboratory has developed a mouse model of chronic Interferon-gamma expression that results in at least 3 different autoimmune diseases resembling lupus, ovarian failure syndrome and primary biliary cholangitis. In addition the male mice exhibit a heart function defect after exercise, This model may provide new insight into the initiation and progression of these diseases and offer novel approaches to treatment.
研究兴趣
论文共 573 篇作者统计合作学者相似作者
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CYTOKINE (2024): 156544-156544
Estefania Viano,Natalia S Baez,Constanza Savid-Frontera, Eliana Baigorrí,Brenda Dinatale,Maria Florencia Pacini,Camila Bulfoni Balbi,Florencia Belén Gonzalez,Laura Fozzatti, Nicolas L Lidón,Howard A Young,Deborah Hodge,
Microbes and infectionpp.105337-105337, (2024)
Enitome E Bafor,Rebecca A Erwin-Cohen, Toni Martin, Clayton Baker, Adrienne E Kimmel, Olivier Duverger,John M Fenimore, Meredith Ramba, Thea Spindel, Megan M Hess,Michael Sanford,Vanja Lazarevic,
Frontiers in immunology (2024): 1368572-1368572
Estefania Viano,Natalia S. Baez,Constanza Savid-Frontera, Eliana Baigorrí,Brenda Dinatale,Maria Florencia Pacini,Camila Bulfoni Balbi,Florencia Belén Gonzalez,Laura Fozzatti, Nicolas L. Lidón,Howard A. Young,Deborah Hodge,
Microbes and Infection (2024)
Estefania Viano,Natalia S. Baez,Constanza Savid-Frontera, Eliana Baigorrí,Brenda Dinatale,Maria Florencia Pacini,Camila Bulfoni Balbi,Florencia Belén Gonzalez,Laura Fozzatti, Nicolas L. Lidón,Howard A. Young,Deborah Hodge,
Microbes and Infectionpp.105337, (2024)
Cancer Researchno. 7_Supplement (2023): 5138-5138
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature (2023)
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Cytokine (2023): 156159-156159
John M Fenimore,Danielle A Springer,Maria E Romero,Elijah F Edmondson, Dan W McVicar, Sudhirkumar Yanpallewar,Michael Sanford, Thea Spindel,Elizabeth Engle,Thomas J Meyer,Julio C Valencia,Howard A Young
The Journal of pathologyno. 3 (2023): 276-288
Frontiers in Immunology (2023): 1021824-1021824
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