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Organisms encounter a diverse array of potentially hazardous substances on a daily basis, including medications, plant and animal toxins, and products of cellular metabolism. An individual's ability to survive these exposures greatly depends upon the efficiency of the excretory and detoxifying organs of the body (e.g., liver, kidney, choroid plexus). Our research focus is on the proteins responsible for the transport of organic solutes in renal proximal tubule, choroid plexus, and brain capillary endothelium. Understanding the mechanisms these transporters utilize to protect the body and brain from fluctuations in the composition of the blood and cerebrospinal fluid will provide unique insight into toxicity, drug-drug interaction, and human disease states. We use Xenopus oocyte, cell culture, intact tissue, and knockout mouse model systems to: (1) determine the energetics and specificity of the transporters, (2) define the roles of transporters in drug interactions and disease, and (3) identify the mechanisms involved in the modulation of transporter function and expression.
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Papers共 88 篇Author StatisticsCo-AuthorSimilar Experts
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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCESno. 15 (2022): 8607-8607
Molecular Cancer Therapeuticsno. 11 (2021): 2207-2217
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