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个人简介
The research in our group is focussed on the development and application of nuclear magnetic resonance (NMR) spectroscopy to study biomacromolecules. Our focus is to contritube to a molecular understanding of fundamental mechanism of biomacromolecules. We investigate proteins - soluble proteins and membrane proteins. We investige RNAs and RNA-protein complexes and unusual DNA structures.
Particular emphasis is on time-resolved NMR experiments; we induce protein, DNA- or RNA-folding by light from compounds that are caged in one (of several) conformations by photolabile protecting groups or natural light-absorbing chromophors. Some of these caged molecules are synthesized in the lab. A different way of inducing biomacromolecular folding is by temperature jump; thus we have developed T-jump probes to do these kind of experiments.
Particular emphasis is on time-resolved NMR experiments; we induce protein, DNA- or RNA-folding by light from compounds that are caged in one (of several) conformations by photolabile protecting groups or natural light-absorbing chromophors. Some of these caged molecules are synthesized in the lab. A different way of inducing biomacromolecular folding is by temperature jump; thus we have developed T-jump probes to do these kind of experiments.
研究兴趣
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BIOspektrumno. 3 (2024): 292-295
ACS CHEMICAL BIOLOGYno. 2 (2024): 563-574
Xavier Jalencas,Hannes Berg,Ludvik Olai Espeland,Sridhar Sreeramulu, Franziska Kinnen,Christian Richter,Charis Georgiou, Vladyslav Yadrykhinsky,Edgar Specker,Kristaps Jaudzems, Tanja Miletic,Robert Harmel,
ACS chemical biologyno. 3 (2024): 607-618
ACS chemical biologyno. 2 (2024): 563-574
Chembiochem : a European journal of chemical biologyno. 10 (2024): e202400049-e202400049
RNA (New York, N.Y.)no. 7 (2024): 779-794
Jennifer Vögele, Elke Duchardt-Ferner,Jasleen Kaur Bains, Bozana Knezic,Anna Wacker,Christian Sich,Julia E Weigand, Jiří Šponer,Harald Schwalbe, Miroslav Krepl,Jens Wöhnert
Nucleic acids researchno. 11 (2024): 6687-6706
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