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Ronald Kaback became interested in membrane transport at a time when studies on biological membranes were in their infancy, and in the early phase of his career, he developed a cell-free membrane system to study active transport. The system consisted of osmotically sealed membrane vesicles of defined orientation (right-side-out) that catalyze active transport essentially as well as intact cells, but lack subsequent metabolism of the solutes accumulated.[4] These vesicles were dubbed Kabackosomes by the Dutch scientist Wilhelmus N. Konings, Kaback's close friend and early collaborator. In addition to transforming the field of transport from phenomenology to biochemistry, this seminal development caused him to forego the practice of pediatrics for a career in basic science. The use of membrane vesicles from various sources has become a standard tool for testing models and performing hypothesis-driven research.
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论文共 255 篇作者统计合作学者相似作者
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Parameswaran Hariharan, Yuqi Shi,Satoshi Katsube,Katleen Willibal, Nathan D Burrows,Patrick Mitchell,Amirhossein Bakhtiiari, Samantha Stanfield,Els Pardon,H Ronald Kaback,Ruibin Liang,Jan Steyaert,
bioRxiv : the preprint server for biology (2023)
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