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Bio
During the last few years, we have dedicated a great deal of time and effort to the establishment of a completely new line of research for our laboratory. We have used our Cell Biology/Pharmacology training as a platform to develop a Drug Discovery line of research designed to take advantage of new advances in molecular medicine and bioinformatics. As part of this strategy, we established all necessary methodology for in silico drug discovery and development approach. Initially, the main focus of this research was to find small drug-like inhibitors with antiviral activity against Influenza-A and Dengue virus. As a result of this effort, we have identified a group of inhibitors with significant broad-spectrum antiviral activity against either all influenza-A or Dengue viruses strains. We are currently pursuing the final identification and characterization of these compounds and are in the process of submitting early next year several research proposals to NIH. More recently, we have applied the same approach to the discovery of inhibitors of the protein kinase Wee-1 with potential applications as cancer therapeutic agents. Preliminary results from these studies are beyond any of our initial expectations since we found ourselves with the unique and rare opportunity of proposing a completely new application for two compounds that have been previously tested for safety in Human Clinical Trials. Encouraged by these preliminary results we are initiating necessary “proof-of-concept” studies to demonstrate the potential of one of these compounds (DW1XN) as a therapeutic agent for several forms of cancer. At the same time, we are establishing in our laboratory all methodology necessary to study the synergistic effects of drug combinations, employing the Wee-1 kinase inhibitor MK-1775 as a model.
Research Interests
Papers共 38 篇Author StatisticsCo-AuthorSimilar Experts
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Gabriel O. Rodríguez-Vázquez,Adriana O. Diaz-Quiñones,Nataliya Chorna, Iris K. Salgado-Villanueva,Jing Tang,Walter I. Silva Ortiz,Héctor M. Maldonado
Gabriel O Rodríguez-Vázquez,Adriana O Diaz-Quiñones,Iris K Salgado,Walter I Silva Ortiz,Héctor M Maldonado
mag(2016)
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#Papers: 32
#Citation: 669
H-Index: 13
G-Index: 25
Sociability: 5
Diversity: 1
Activity: 0
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