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Our research programme uses large scale population based approaches to further our understanding of the pathogenesis and means of prevention of diabetes complications. A main component of our current work harnesses the increasing availability of e-health record data (EHR) and new technologies for acquiring high dimensional molecular ‘omics data. We quantify contemporaneous absolute risks of complications, evaluate risk factors for complications, and build prediction models using e-health record data. These data are used to inform current health care policy and clinical practice in diabetes. We also use large bioresources linked to these data to quantify the marginal improvement gained by genetics and biomarker panels beyond that achieved by EHR data. Our aim is that these prediction algorithms will then be incorporated into prediction tools for clinical and self-management, and will be useful in clinical trial design. These genetics and biomarker studies also yield important information on the pathogenesis of diabetes complications, that, with more detailed wet-lab research with colleagues in the Institute of Genetics and Cancer, can inform future development of new therapies. Our research programme also encompasses the design and conduct of clinical trials of new drugs and approaches for preventing diabetes complications.
Research Interests
Papers共 444 篇Author StatisticsCo-AuthorSimilar Experts
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medrxiv(2024)
Esther Latres,Carla J Greenbaum, Maria L Oyaski,Colin M Dayan,Helen M Colhoun,John M Lachin,Jay S Skyler,Michael R Rickels,Simi T Ahmed, Sanjoy Dutta,Kevan C Herold,Marjana Marinac
Diabetes (2024)
Joe Mellor,Anita Jeyam, Joline WJ. Beulens,Sanjeeb Bhandari, Geoffrey Broadhead,Emily Chew,Ward Fickweiler,Amber van der Heijden,Daniel Gordin,Rafael Simó,Janet Snell-Bergeon,Anniina Tynjälä,
Ophthalmology Scienceno. 4 (2024): 100494-100494
Joseph Mellor,Dmitry Kuznetsov,Simon Heller,Mari-Anne Gall,Myriam Rosilio,Stephanie A. Amiel,Mark Ibberson,Stuart McGurnaghan,Luke Blackbourn, William Berthon, Adel Salem, Yongming Qu,
Diabetologiapp.1-14, (2024)
Nephrology Dialysis Transplantationno. Supplement_1 (2024)
Stuart J McGurnaghan,Paul M McKeigue,Luke A K Blackbourn, Joseph Mellor,Thomas M Caparrotta,Naveed Sattar,Brian Kennon, David McAllister,Sarah H Wild,Helen M Colhoun, Scottish Diabetes Research Network Epidemiology Group
Diabetes care (2024)
NATURE MEDICINEpp.1-9, (2024)
JOURNAL OF APPLIED PHYSIOLOGYno. 1 (2024): 13-22
Kunihiko Aizawa,Alun D Hughes, Francesco Casanova, Kim M Gooding,Phillip E Gates, David M Mawson, Jennifer Williams,Isabel Goncalves,Jan Nilsson, Faisel Khan,Helen M Colhoun,Carlo Palombo,
ESC heart failure (2024)
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