基本信息
浏览量:203
![](https://originalfileserver.aminer.cn/sys/aminer/icon/show-trajectory.png)
个人简介
Together with Barry Sharpless and M.G. Finn, Kolb developed the concept of click chemistry, an approach to simplify synthesis by focusing on a few chemical reactions that are similar in nature. The associated scientific publication Click chemistry: diverse chemical function from a few good reactions has been cited more than 14,000 times (as of 2021) and was awarded the 2022 Nobel Prize in Chemistry for K. Barry Sharpless, Carolyn Bertozzi and Morten Meldal. Kolb refined the method by combining it as in-situ click chemistry with microfluidic processes. This makes it particularly easy to synthesize new inhibitors for various enzymes. Kolb's more recent work deals with the synthesis of new tracers for positron emission tomography (e.g. for detecting the tau protein in Alzheimer's disease) and with the clinical testing of these tracers, a key highlight being [18F]-T807, also known as AV1451, Flortaucipir, Tauvid, which was approved in 2020 by the US food and drug administration (FDA) for imaging neurofibrillary tangles in adults who are being evaluated for Alzheimer’s Disease.
Kolb’s lab has developed a blood plasma assay for phospho-217-Tau (p217Tau), which shows potential as a highly accurate peripheral biomarker for amyloid and Tau status in Alzheimer’s Disease.
Kolb’s lab has developed a blood plasma assay for phospho-217-Tau (p217Tau), which shows potential as a highly accurate peripheral biomarker for amyloid and Tau status in Alzheimer’s Disease.
研究兴趣
论文共 345 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
D. Angioni, J. Cummings, C. J. Lansdall, L. Middleton,C. Sampaio,S. Gauthier, S. Cohen,R. C. Petersen,D. M. Rentz,A. M. Wessels,S. B. Hendrix, F. Jessen,
The Journal of Prevention of Alzheimer's Diseasepp.1-9, (2024)
Communications biologyno. 1 (2024): 528-528
Communications Biologyno. 1 (2024): 1-13
medRxiv : the preprint server for health sciences (2024)
A. Feizpour,V. Doré,J. D. Doecke,Z. S. Saad, G. Triana-Baltzer, R. Slemmon,P. Maruff,N. Krishnadas,P. Bourgeat, K. Huang,C. Fowler,S. R. Rainey-Smith,
JPAD-JOURNAL OF PREVENTION OF ALZHEIMERS DISEASEno. 4 (2023): 828-836
Alzheimer's & dementia : the journal of the Alzheimer's Associationno. 10 (2023): 4463-4474
Nature agingno. 10 (2023): 1210-1218
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn