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Dr. Blair is a member of the Division of Clinical Chemistry in the Section of Laboratory Medicine, and is a VA Merit Investigator and Staff Pathologist.
I investigate the regulation of bone turnover and the mechanisms by which bone is deposited and resorbed. I use human models including human mesenchymal stem cells, which differentiate into bone-forming osteoblasts, and human monocytes, which differentiate into macrophages and osteoclasts. I also study selected related topics in clinical chemistry; currently these include the mechanisms by which trans-fatty acids cause pathology by interfering with fatty acid catabolism in macrophages. Major current projects include regulation of osteoclast formation by calcium; the role of glycoprotein hormones, traditionally thought of as pituitary-endocrine regulators, in direct action on bone turnover. New projects in development include regulation by PTH of osteoblast transport, and osteoblast acid transport and matrix vesicle activity. Research support added over the past year includes an RO1 (multi PI, I am the submitting PI), and my VA Merit was recently scored in the funding range. Two additional RO1 applications are pending review.
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American journal of physiology. Cell physiologyno. 3 (2024): C843-C849
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGYno. 3 (2024): C843-C849
Bone Reports (2024)
Bone reports (2024): 101763-101763
JOURNAL OF CELLULAR BIOCHEMISTRYno. 12 (2023): 1889-1899
American journal of physiology. Cell physiologyno. 3 (2023): C613-C622
JOURNAL OF BONE AND MINERAL RESEARCH (2023): 228-229
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biorxiv(2023)
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