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职业迁徙
个人简介
My entire career has been focused on defining the trafficking of cellular and molecular cargo out of tissues to distal lymph nodes or downstream organs and the relationship of such trafficking to chronic inflammatory disease. Early on, I focused on monocytes, aiming to define whether the ability of an inflamed tissue to clear monocyte-derived cells that had accumulated during inflammation might involve, at least in part, their migratory egress from the tissue via a return to blood or lymph. I devised approaches to label monocytes with phagocytic cargo to address this question and found trafficking of some of the labeled cells to lymph nodes, with the monocyte-derived cells that emigrated to lymph nodes possessing some features of dendritic cells. This work led my group to develop strategies to study and characterize both conventional dendritic cell migration and monocyte-derived cell migration through lymphatics to lymph nodes in tissues like skin, lung, and bladder. We also considered the lymphatic vasculature and defined how the lymphatic remodeling was coordinated in lymph nodes, via lymphotoxin-expressing B cells, to promote dendritic cell entry from lymph in balance with the recruitment of lymphocytes coming in from the HEV. From the monocyte perspective, we compared and characterized the phenotype and migratory properties of human and mouse monocyte subsets, with an interest in understanding what features led a monocyte to become an emigratory cell versus a macrophage that does not readily emigrate to lymph nodes from tissues.
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Michael R Strickland,Michael J Rau,Brock Summers,Katherine Basore, John Wulf, Hong Jiang, Yun Chen,Jason D Ulrich,Gwendalyn J Randolph, Rui Zhang,James A J Fitzpatrick,Anil G Cashikar,
Neuronno. 7 (2024): 1100-1109.e5
SCIENCE IMMUNOLOGYno. 94 (2024)
Rachel Mintz,Alexandre Gallerand, Jichang Han, Sarah Ning,Wei Zou,Mary Wohltmann,Bernd Zinselmeyer,Gwendalyn Randolph
CANCER RESEARCHno. 5 (2024)
Gwendalyn Randolph,Emma Erlich,Rafael Czepielewski,Rachael Field, Taylor Dunning,Leila Saleh, Mark Hoofnagle, Alexei Tumanov,Farshid Guilak,Jonathan Brestoff
Research square (2024)
Fan Yang, Mingyi Suo, Homayemem Weli, Mason Wong, Alex Junidi,Celeste Cummings,Ryan Johnson, Kiara Mallory,Annie Y. Liu,Zev J. Greenberg,Laura G. Schuettpelz,Mark J. Miller,
Cell Reportsno. 11 (2023): 113394-113394
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