基本信息
views: 11
![](https://originalfileserver.aminer.cn/sys/aminer/icon/show-trajectory.png)
Bio
I graduated with a BSc in Zoology and Animal Physiology from the University of East Anglia in 1979. After 3 years working for the Ministry of Agriculture, Fisheries and Food inspecting export grain for insect infestation, I began my research career with a PhD position in the Department of Physiology, King’s College London with Dr David A Tonge. This initiated my research interest studying how appropriate nerve-muscle connections are made and then adapted to their diverse functions. I gained my PhD in 1986, investigating the regeneration of nerve-muscle connections. Subsequent postdoctoral work investigated other aspects of neuromuscular function. First, with Prof Glen Cottrell in St Andrews, investigating how simple (acetylcholine) and complex (neuropeptides) molecules, called 'neurotransmitters', are used simultaneously for neuromuscular signalling. Later, I worked in the Department of Physiology, University of Bristol with Dr Tony Ridge, studying the developmental pruning of nerve-muscle connections. This led to a major 2-year period at the University of Colorado Health Sciences Center, Denver, Colorado, USA. Here, with Dr Bill Betz, we developed technique for using FM1-43 and related dyes for fluorescent studies of the kinetics and distribution of the tiny neurotransmitter packets (vesicles) during activity in living nerve terminals. Between 1991 and 1994, I worked with Prof Clarke Slater in the Muscular Dystrophy Group Research Laboratories, Newcastle General Hospital investigating the role of muscular dystrophy-related structural proteins in building nerve-muscle specialisations. I was appointed to a Lectureship in Biomedical Sciences, University of Aberdeen, in 1994 and promoted to Senior Lecturer in 2001.
Research Interests:
Dr Bewick’s research interests are centred on understanding how appropriate nerve-muscle signalling is established and maintained, both in motor and sensory systems. One focus is elucidating the role of the intriguing system of synaptic-like vesicles in mechanically sensitive sensory endings, he uncovered in collaboration with Dr Robert Banks of Durham University. This vesicle-based system seems to regulate the excitability of these sensory endings over a wide range, and is even capable of turning off the ending entirely. The other focus is on the neuromuscular junction, where he is examining how transmitter release from the motor terminal is maintained over a range of in vivo activity patterns. As well as understanding the basic neuroscience, he is exploring these control mechanisms as potential targets for strategies to ameliorate weakness in neuromuscular diseases.
Research Interests
Papers共 76 篇Author StatisticsCo-AuthorSimilar Experts
By YearBy Citation主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Karen J. Thompson,Sonia Watson,Chiara Zanato,Sergio Dall'Angelo,Joriene C. De Nooij, Bethany Pace-Bonello,Fiona C. Shenton,Helen E. Sanger,Beverly A. Heinz,Lisa M. Broad,Noelle Grosjean, Jessica R. Mcquillian,
Experimental Physiologyno. 1 (2024): 81-99
Stephen N Housley, Randal K Powers,Paul Nardelli,Sebinne Lee,Kyle Blum,Guy S Bewick,Robert W Banks,Timothy C Cope
Experimental Physiologyno. 1 (2024): 55-65
Arimantas Lionikas,Ana I. Hernandez Cordero, Audrius Kilikevicius, Andrew M. Carroll,Guy S. Bewick, Lutz Bunger, Aivaras Ratkevicius, Lora K. Heisler, Mette Harboe,Claus Oxvig
FRONTIERS IN MOLECULAR NEUROSCIENCE (2023): 1169075-1169075
Load More
Author Statistics
#Papers: 71
#Citation: 3223
H-Index: 24
G-Index: 56
Sociability: 7
Diversity: 3
Activity: 3
Co-Author
Co-Institution
D-Core
- 合作者
- 学生
- 导师
Data Disclaimer
The page data are from open Internet sources, cooperative publishers and automatic analysis results through AI technology. We do not make any commitments and guarantees for the validity, accuracy, correctness, reliability, completeness and timeliness of the page data. If you have any questions, please contact us by email: report@aminer.cn