基本信息
views: 0
![](https://originalfileserver.aminer.cn/sys/aminer/icon/show-trajectory.png)
Bio
Our research aim is to define the transport processes of sodium and water and their control mechanisms in the renal collecting tubule. Two areas of investigation are being pursued. First, we have recently described in freshly dissected tubules the changes in activity of single sodium channels from the apical membrane of principal cells caused by variations in the intracellular sodium level. Channel activity is decreased when the rate of sodium entry into the cell temporarily exceeds that of sodium exit through the sodium pump, and increased when the rate of sodium entry is decreased. At the present we are studying whether calcium ion-dependent kinases are involved in the regulation of these sodium channels under conditions of changes in cell sodium. Second, we have cloned a protein located in the medullary collecting duct of the rat kidney that is a water channel when it is expressed in Xenopus laevis oocytes. This protein is a member of a family of membrane intrinsic proteins. Now we are studying the exact localization of the protein in the nephron cells and other organs, the selectivity of the channel for some small organic solutes, and whether the channel is regulated by the level of vasopressin and/or the water balance of the animal.
Research Interests
Papers共 66 篇Author StatisticsCo-AuthorSimilar Experts
By YearBy Citation主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
American journal of physiology. Renal physiologyno. 2 (2023): F224-F234
PHYSIOLOGYno. S1 (2023)
Load More
Author Statistics
Co-Author
Co-Institution
D-Core
- 合作者
- 学生
- 导师
Data Disclaimer
The page data are from open Internet sources, cooperative publishers and automatic analysis results through AI technology. We do not make any commitments and guarantees for the validity, accuracy, correctness, reliability, completeness and timeliness of the page data. If you have any questions, please contact us by email: report@aminer.cn