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My research program aims at understanding the evolution of complex characters. This problem has many dimensions, including the question how complex characters can evolve by random mutation and selection (i.e. evolvability, the evolution of evolvability, the role of modularity etc), the biological nature of character identity (homology) and the genetic mechanisms for the origin of novel characters. Most of the effort in my lab focuses on the evolution of the gene regulatory network underlying the origin of a novel cell type, the endometrial stromal cells of placental mammals. This research led us towards an investigation of the role of transcription factor protein evolution in particular the origin of novel protein-protein interactions. The second focus is the developmental basis of avian digit identity. Ever since the discovery that birds are dinosaurs we face the problem whether avian wing digits are 1,2, 3, or 2, 3, 4. All these empirical research problems bring with them a host of conceptual and theoretical problems that I also like to address, such as the nature of character individuation, the structure of the homology concept and the role of measurement theory in formulating evolutionary models.
Research Interests
Papers共 332 篇Author StatisticsCo-AuthorSimilar Experts
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Daniel J Stadtmauer, Silvia Basanta,Jamie D Maziarz,Alison G Cole, Gülay Dagdas, Gilbecca Rae Smith, Frank van Breukelen,Mihaela Pavličev,Günter P Wagner
bioRxiv : the preprint server for biology (2024)
Theory in Biosciencesno. 1 (2024): 45-62
ISCIENCEno. 1 (2024): 108593-108593
TRENDS IN ECOLOGY & EVOLUTIONno. 7 (2023): 595-596
EVOLVABILITY: A Unifying Concept in Evolutionary Biology?pp.199-219, (2023)
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Trends in ecology & evolutionno. 10 (2023): 903-904
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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