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个人简介
Research in my lab is organised around three main themes: i) the cellular actin cortex; ii) mechanics of cells and tissues, and iii) cell migration in confined environments.
The first theme seeks to understand the dynamic molecular mechanisms responsible for homeostasis of the submembranous actin cortex in cells. Combining proteomics and siRNA screening, we have uncovered the actin nucleators responsible for generation of the cell cortex as well as its proteic composition (Bovellan et al, Current Biology, 2014; Cao et al, Nature Cell Biology, 2020). The ultimate goal of this research is to understand cortical mechanics from the bottom-up using Scanning Electron Microscopy, mechanical characterisation by Atomic Force Microscopy, and polymer physics theories.
The first theme seeks to understand the dynamic molecular mechanisms responsible for homeostasis of the submembranous actin cortex in cells. Combining proteomics and siRNA screening, we have uncovered the actin nucleators responsible for generation of the cell cortex as well as its proteic composition (Bovellan et al, Current Biology, 2014; Cao et al, Nature Cell Biology, 2020). The ultimate goal of this research is to understand cortical mechanics from the bottom-up using Scanning Electron Microscopy, mechanical characterisation by Atomic Force Microscopy, and polymer physics theories.
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