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Bio
Biography
It is clear that improvement in our ability to cure children with brain tumours and reduce the considerable morbidity will only come through a better understanding of the underlying biology of these varied and presently difficult to treat tumours. The principal aim of my research is based on this philosophy. Our research programme includes the use of DNA and RNA microarray technologies to identify biological correlates of tumour behaviour; to elucidate the underlying molecular alterations of each tumour type and to validate novel targets for the development of new drug therapies. In addition to my research activities at the Children's Brain Tumour Research centre, I also have an active interest in the development and conduct of clinical trials in CNS tumours and am a long standing member of the Children's Cancer Leukaemia Group CNS division. I am Chief investigator of the International Society of Paediatric Oncology Ependymoma study and heavily involved in discussions over the next Ependymoma trial. I am also Chair of the Biology Committee of the UK Paediatric Brain Tumour Consortium and am a Co-Investigator on a number of Children's Cancer Leukaemia, Group Clinical and Biological studies.
Current Research
We have a major research programme investigating the molecular genetics of childhood brain tumours using cutting edge high resolution genetic analysis. We are developing biostatistical infrastructure to maximise the use of the data in our increasingly large data base
It is clear that improvement in our ability to cure children with brain tumours and reduce the considerable morbidity will only come through a better understanding of the underlying biology of these varied and presently difficult to treat tumours. The principal aim of my research is based on this philosophy. Our research programme includes the use of DNA and RNA microarray technologies to identify biological correlates of tumour behaviour; to elucidate the underlying molecular alterations of each tumour type and to validate novel targets for the development of new drug therapies. In addition to my research activities at the Children's Brain Tumour Research centre, I also have an active interest in the development and conduct of clinical trials in CNS tumours and am a long standing member of the Children's Cancer Leukaemia Group CNS division. I am Chief investigator of the International Society of Paediatric Oncology Ependymoma study and heavily involved in discussions over the next Ependymoma trial. I am also Chair of the Biology Committee of the UK Paediatric Brain Tumour Consortium and am a Co-Investigator on a number of Children's Cancer Leukaemia, Group Clinical and Biological studies.
Current Research
We have a major research programme investigating the molecular genetics of childhood brain tumours using cutting edge high resolution genetic analysis. We are developing biostatistical infrastructure to maximise the use of the data in our increasingly large data base
Research Interests
Papers共 454 篇Author StatisticsCo-AuthorSimilar Experts
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Simrandip K Gill,Heather E L Rose,Martin Wilson,Daniel Rodriguez Gutierrez,Lara Worthington,Nigel P Davies,Lesley MacPherson, Darren R Hargrave,Dawn E Saunders, Christopher A Clark,Geoffrey S Payne, Martin O Leach,
Marwa Deghedy, Martin English, Helen Curry,James Nicholson, Patricia O’Hare, Anthony McCarthy, Lena Uzunova, Sarah Curry, Shaun Wilson, Mette Jorgensen, Dominic Thompson, Rachel Cox,
Neuro-Oncologyno. Supplement_4 (2024): 0-0
EBioMedicine (2024): 104958
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Teddy Zhao,James T Grist,Dorothee P Auer,Shivaram Avula, Simon Bailey,Nigel P Davies,Richard G Grundy, Omar Khan,Lesley MacPherson, Paul S Morgan,Barry Pizer,Heather E L Rose,
Nico V. Henriquez,Tim Forshew,Ruth Tatevossian,Matthew Ellis,Angela Richard-Loendt,Hazel Rogers, Thomas S. Jacques,Pablo Garcia Reitboeck,Kerra Pearce,Denise Sheer,Richard G. Grundy, Sebastian Brandner
crossref(2023)
Nico V. Henriquez,Tim Forshew,Ruth Tatevossian,Matthew Ellis,Angela Richard-Loendt,Hazel Rogers, Thomas S. Jacques,Pablo Garcia Reitboeck, Kerra Pearce,Denise Sheer,Richard G. Grundy, Sebastian Brandner
crossref(2023)
Rebecca Chapman,David R. Ghasemi,Felipe Andreiuolo,Valentina Zschernack,Arnault Tauziede Espariat,Francesca Romana Buttarelli, Felice Giangaspero,Jacques Grill,Christine Haberler,Simon Paine,Ian C. Scott, Thomas S. Jacques,
Neuro-Oncologyno. Supplement_1 (2023): i26-i27
crossref(2023)
iScienceno. 9 (2023): 107585-107585
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