基本信息
浏览量:44
职业迁徙
个人简介
In canonical G protein signaling, G protein coupled receptors (GPCRs) activate heterotrimeric G proteins, which in turn regulate intracellular effector enzymes. Our lab studies G protein signaling and new classes of enzymes that activate heterotrimeric G proteins apart from GPCR-initiated activation. We found the biochemical function of one new G protein activator, Ric-8. Ric-8A activates G protein alpha subunits by serving as a guanine nucleotide exchange catalyst. A major focus of our research group is to investigate the physiological roles that Ric-8 proteins have in directing non-traditional G protein signaling pathways in the cell. Observations made in genetic model systems suggest that Ric-8 proteins work with G proteins to regulate asymmetric cell division, the subcellular localization of G protein subunits, and as modulators of traditional GPCR signaling.
My primary research interests focus on G protein signaling and new classes of enzymes that activate heterotrimeric G proteins apart from GPCR-initiated activation. The effort in my lab has elucidated the biochemical function of a newly discovered G protein activator, Ric-8A, and how it activates G protein alpha subunits by serving as a guanine nucleotide exchange catalyst. Another focus of our research group is to investigate the physiological roles that Ric-8 proteins have in directing non-traditional G protein signaling pathways in the cell.
My primary research interests focus on G protein signaling and new classes of enzymes that activate heterotrimeric G proteins apart from GPCR-initiated activation. The effort in my lab has elucidated the biochemical function of a newly discovered G protein activator, Ric-8A, and how it activates G protein alpha subunits by serving as a guanine nucleotide exchange catalyst. Another focus of our research group is to investigate the physiological roles that Ric-8 proteins have in directing non-traditional G protein signaling pathways in the cell.
研究兴趣
论文共 74 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Dominic Lapadula,Eduardo Farias,Clinita E. Randolph,Timothy J. Purwin, Dougan McGrath,Thomas H. Charpentier, Lihong Zhang,Shihua Wu,Mizue Terai,Takami Sato,Gregory G. Tall,Naiming Zhou,
crossref(2023)
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2023)
JOURNAL OF BIOLOGICAL CHEMISTRYno. 10 (2023)
Molecular pharmacologyno. 1 (2023): 28-41
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn