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Dr. Dressler studied Bioengineering and Chemical Engineering before receiving his Ph.D. in Molecular Genetics from the University of Pennsylvania. He was a post-doctoral fellow in the lab of Peter Gruss at the Max Planck Institute for Biophysical Chemistry where he helped discover the Pax gene family and characterized the Pax2 gene in the developing kidney and nervous system. As a staff fellow at the National Institute of Child Health and Human Development he began his studies on Pax2 and kidney development and disease. His lab showed that Pax2 was expressed in renal progenitor cells and in renal carcinoma and Wilms' tumor, but not in normal adult proximal tubules. Using genetic and biochemical models, he showed that deregulation of Pax2 led to severe kidney abnormalities. After coming to Michigan as a HHMI Assistant Investigator, he showed that glial-cell derived neurotrophic factor was the ligand for the c-ret tyrosine kinase and promoted renal epithelial cell migration in the developing kidney. The Dressler lab went on to discover the Kielin/Chordin-like Protein (KCP), the first secreted enhancer of BMP signaling and showed that this protein was important for mediating fibrotic disease in the kidney and liver. The lab also discovered PTIP, and adaptor protein that links the Pax family of DNA binding proteins to the MLL family of histone H4, lysine 4 methyltransferases. This work defined a new paradigm for how developmental regulatory proteins can imprint cell lineage specificity through epigenetic modification of the genome.
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Scientific reportsno. 1 (2023): 6361-13
Oral Presentations - Proffered Abstracts (2020)
Kidney Development, Disease, Repair and Regenerationpp.17-26, (2016)
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