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In canonical G protein signaling, G protein coupled receptors (GPCRs) activate heterotrimeric G proteins, which in turn regulate intracellular effector enzymes. Our lab studies G protein signaling and new classes of enzymes that activate heterotrimeric G proteins apart from GPCR-initiated activation. We found the biochemical function of one new G protein activator, Ric-8. Ric-8A activates G protein alpha subunits by serving as a guanine nucleotide exchange catalyst. A major focus of our research group is to investigate the physiological roles that Ric-8 proteins have in directing non-traditional G protein signaling pathways in the cell. Observations made in genetic model systems suggest that Ric-8 proteins work with G proteins to regulate asymmetric cell division, the subcellular localization of G protein subunits, and as modulators of traditional GPCR signaling.
My primary research interests focus on G protein signaling and new classes of enzymes that activate heterotrimeric G proteins apart from GPCR-initiated activation. The effort in my lab has elucidated the biochemical function of a newly discovered G protein activator, Ric-8A, and how it activates G protein alpha subunits by serving as a guanine nucleotide exchange catalyst. Another focus of our research group is to investigate the physiological roles that Ric-8 proteins have in directing non-traditional G protein signaling pathways in the cell.
My primary research interests focus on G protein signaling and new classes of enzymes that activate heterotrimeric G proteins apart from GPCR-initiated activation. The effort in my lab has elucidated the biochemical function of a newly discovered G protein activator, Ric-8A, and how it activates G protein alpha subunits by serving as a guanine nucleotide exchange catalyst. Another focus of our research group is to investigate the physiological roles that Ric-8 proteins have in directing non-traditional G protein signaling pathways in the cell.
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Dominic Lapadula,Eduardo Farias,Clinita E. Randolph,Timothy J. Purwin, Dougan McGrath,Thomas H. Charpentier, Lihong Zhang,Shihua Wu,Mizue Terai,Takami Sato,Gregory G. Tall,Naiming Zhou,
crossref(2023)
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2023)
JOURNAL OF BIOLOGICAL CHEMISTRYno. 10 (2023)
Molecular pharmacologyno. 1 (2023): 28-41
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