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Dr Grant Parnell is a Lecturer in Bioinformatics at the School of Medical Sciences, Faculty of Medicine and Health, University of Sydney and a research group leader with a strong focus on the translation of transcriptomic and genomic technologies into clinical practice. He leads the Immunogenetics Group based at the Centre for Immunology and Allergy Research at the Westmead Institute for Medical Research. The aim of his current research program is to investigate the role of the vitamin D receptor in myeloid cell differentiation and immunological tolerance, using ATACseq, ChIPseq and RNAseq. He is also involved in projects aimed at understanding the interaction between multiple sclerosis risk genes with environmental risk factors such as low vitamin D level and Epstein-Barr virus infection.
Grant was awarded his PhD from the University of Sydney in 2014 for his work on transcriptome profiling of the immune response in patients admitted to intensive care due to systemic infection. This research identified distinct differences in the immune response in patients with pneumonia caused by bacterial as opposed to influenza infection. As part of this work, a single gene biomarker, IFI27, was identified that is capable of stratification of severity of infection in influenza infected individuals. He is a co-inventor on an international patent awarded for this biomarker. His research to date has required development of expertise in experimental design, laboratory procedures, and bioinformatics analysis for large scale transcriptomic studies. He was responsible for both his PhD lab and current research group’s transition from microarray based to next-generation sequencing transcriptomic approaches, both wet-and-dry lab aspects.
Grant was awarded his PhD from the University of Sydney in 2014 for his work on transcriptome profiling of the immune response in patients admitted to intensive care due to systemic infection. This research identified distinct differences in the immune response in patients with pneumonia caused by bacterial as opposed to influenza infection. As part of this work, a single gene biomarker, IFI27, was identified that is capable of stratification of severity of infection in influenza infected individuals. He is a co-inventor on an international patent awarded for this biomarker. His research to date has required development of expertise in experimental design, laboratory procedures, and bioinformatics analysis for large scale transcriptomic studies. He was responsible for both his PhD lab and current research group’s transition from microarray based to next-generation sequencing transcriptomic approaches, both wet-and-dry lab aspects.
Research Interests
Papers共 70 篇Author StatisticsCo-AuthorSimilar Experts
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Frontiers in cellular and infection microbiology (2024): 1346821-1346821
Clinical & translational immunologyno. 6 (2023)
MULTIPLE SCLEROSIS JOURNALno. 4_SUPPL (2022): 30-30
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MULTIPLE SCLEROSIS JOURNALno. 4_SUPPL (2022): 20-21
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Contact Lens and Anterior Eyeno. 4 (2022): 101494-101494
MULTIPLE SCLEROSIS JOURNALno. 4_SUPPL (2022): 37-37
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Jeremy Thomas Keane, Ali Afrasiabi, Stephen Donald Schibeci, Sanjay Swaminathan,Grant Peter Parnell, David Richmond Booth
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Author Statistics
#Papers: 65
#Citation: 1494
H-Index: 21
G-Index: 38
Sociability: 6
Diversity: 0
Activity: 1
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