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个人简介
Research
Gracjan’s main research interests are associated with regulation of gene expression, RNA processing and innate immune response to RNA viruses. He discovered a number of factors and mechanisms that regulate production of miRNAs (short non-coding RNAs that control physiological and pathological gene expression pathways). He demonstrated that E3 ubiquitin ligase TRIM25 (a key player in innate immune response to RNA viruses) is a novel RNA-binding protein. Finally, Gracjan showed that Oleic Acid (a natural ω-9 monounsaturated fatty acid produced by various plants and animal cells) directly stimulates the production of tumour suppressor miRNA. His findings have far reaching consequences for our understanding of how RNA-binding proteins and metabolites regulate gene expression, RNA processing and innate immunity.
Gracjan’s main research interests are associated with regulation of gene expression, RNA processing and innate immune response to RNA viruses. He discovered a number of factors and mechanisms that regulate production of miRNAs (short non-coding RNAs that control physiological and pathological gene expression pathways). He demonstrated that E3 ubiquitin ligase TRIM25 (a key player in innate immune response to RNA viruses) is a novel RNA-binding protein. Finally, Gracjan showed that Oleic Acid (a natural ω-9 monounsaturated fatty acid produced by various plants and animal cells) directly stimulates the production of tumour suppressor miRNA. His findings have far reaching consequences for our understanding of how RNA-binding proteins and metabolites regulate gene expression, RNA processing and innate immunity.
研究兴趣
论文共 51 篇作者统计合作学者相似作者
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Magdalena Wolczyk,Jacek Szymanski,Ivan Trus, Zara Naz, Agnieszka Bolembach,Nila Roy Choudhury, Tola Tame, Ceren Konuc,Elzbieta Nowak,Christos Spanos, Juri Rappsilber,Gracjan Michlewski
biorxiv(2023)
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Roseanne Rosario,Hazel Stewart,Nila Roy Choudhury,Gracjan Michlewski, Nicolas Charlet-Berguerand,Richard (A) Anderson
crossref(2021)
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