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Our lab studies the structure and dynamics of proteins, protein-protein complexes, and protein-nucleic acid complexes using multidimensional nuclear magnetic resonance (NMR) spectroscopy, and we develop and apply novel NMR and computational methods to aid in these studies. We are particularly interested in complexes involved in signal transduction and transcriptional regulation, and on AIDS and AIDS-related proteins. More recently we have focused on the development of novel NMR methods to detect, visualize, and characterize transient, sparsely-populated states of macromolecules. Such states, which are invisible to conventional biophysical techniques, including crystallography, play a critical role in macromolecular recognition, allostery induced fit, conformational selection, and molecular assembly. Dr. Clore is a Fellow of the Royal Society, a Member of the National Academy of Sciences, a Fellow of the American Academy of Arts and Sciences, and a Foreign Member of the Academia Europaea. Prizes and awards include the Royal Society of Chemistry Centenary and Khorana Prizes, the Biochemical Society (U.K.) Centenary Award, The Biophysical Society Innovation Award, and the Biopolymers Murray Goodman Memorial Prize.
Research Interests
Papers共 841 篇Author StatisticsCo-AuthorSimilar Experts
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合作机构
Journal of the American Chemical Societyno. 26 (2024): 17964-17973
The journal of physical chemistry lettersno. 24 (2024): 6375-6382
Advanced Scienceno. 24 (2024): n/a-n/a
Proceedings of the National Academy of Sciences of the United States of Americano. 21 (2023): e2305823120-e2305823120
Journal of biomolecular NMRno. 3 (2023): 83-91
The Journal of biological chemistryno. 4 (2023): 103037-103037
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Author Statistics
#Papers: 844
#Citation: 99939
H-Index: 153
G-Index: 298
Sociability: 7
Diversity: 3
Activity: 81
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