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Bio
The Nuñez laboratory is interested in host-microbial interactions, the pathogenesis of inflammatory disease and the role of the microbiota in host defense and disease. Specifically, the research focuses on mechanistic studies to understand the role of members of the Nod-like receptor (NLR) and Toll-like receptor (TLR) families in immune responses against microbial pathogens and inflammatory disease. Current studies focus on models of intestinal and skin inflammation driven by microbial pathogens, commensal bacteria and sterile organ injury. Several approaches that include analyses of genetically modified mutant mice and biochemical studies are used to understand NLR signaling pathways including those that activate the inflammasomes. In addition, the laboratory is devoting a major effort in understanding the role of the microbiota in the regulation of immune responses, eradication of pathogens and development of inflammatory disease in the gut and the skin. These studies include work to elucidate the role of the microbiota in colonization resistance against bacterial pathogens in neonates and new approaches to provide neonatal protection against enteric pathogens.
Research Interests
Papers共 732 篇Author StatisticsCo-AuthorSimilar Experts
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SCIENCEno. 6678 (2024): 62-70
INFLAMMATORY BOWEL DISEASESno. 12 (2024): S16-S17
Science (New York, N.Y.)no. 6678 (2024): 62-70
Reika Aoyama, Seitaro Nakagawa, Yoko Ichikawa,Naohiro Inohara,Yuriko Yamazaki, Tomoka Ito,Takashi Sugihira,Michihiro Kono,Masashi Akiyama,Hiroki Takahashi,Akiko Takaya, Fumitaka Ichikawa,
GUT MICROBESno. 1 (2024): 2333463-2333463
Gabriel Núñez, Claudia Secchi
Actualización en nutrición.no. 1 (2023)
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