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Bio
Giuseppe Iacomino is a senior and staff scientist at Istituto di Scienze dell’Alimentazione – Consiglio Nazionale delle Ricerche (CNR). In 1989 he got his Laurea degree cum laude in Biological Science at University of Naples. From 1988 to 1990 he worked in the laboratories of Prof. Zappia (Biochemistry, Faculty of Medicine – University of Naples), and from 1991 to 1997 in the laboratories of Prof. Cascino (Molecular Biology, Faculty of Medicine – University of Naples). He has a Ph.D in Biochemistry and is specialised in Biochemistry and Clinical Chemistry. G. Iacomino has over 30 years of experience in the fields of Biochemistry, Cell Biology, Molecular Biology, Cancer prevention, Cancer Biology, and Nutritional Biochemistry.
His research has focused, at molecular level, on different aspects of food, from chemo-prevention to diet-related diseases.
His main expertise is on epigenomics, on gene expression control, on the role of chromatin modifiers in affecting the transcriptional activity, on the cell cycle and apoptosis. In this respect, the downstream effects of nutrients with chromatin modifying ability are emerging as fundamental aspects contributing to the response to food and individual nutrients intake. Besides, Scientific interests are focused on the role of polyamines in governing the nuclear organization: we firstly found that polyamines self-assemble in the cell nucleus and generate compounds referred to as nuclear aggregates of polyamines (NAPs) which interact with genomic DNA and regulate decisive aspects of DNA physiology, such as conformation, protection and packaging. His research activity is also focused on the differential signature of microRNAs in obesity and metabolic diseases.
Moreover, scientific interests cover the valorization of food and food products influencing consumer health by studying the bio-accessibility, bio-transformation, and transport using models of simulated digestion and human intestinal cells.
He regularly reviews scientific manuscripts for international journals in the fields of cell and molecular biology, nutritional biochemistry, food related disorders, and grant applications. He is involved in Editorial activity for the Journal "Genes" MDPI. He regularly presents his research activity at meetings and seminars.
Research Interests
Papers共 58 篇Author StatisticsCo-AuthorSimilar Experts
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FOODSno. 5 (2024): 661
GENESno. 2 (2023): 314-314
Journal of clinical medicineno. 16 (2023): 5362-5362
Biomarkers in Disease: Methods, Discoveries and Applications Biomarkers in Nutritionpp.495-516, (2022)
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