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职业迁徙
个人简介
My independent research has focused on pediatric sarcomas, specifically a group termed "primitive round cell sarcomas (PRCSs)."
PRCSs are a unique group of undifferentiated sarcomas composed of primitive mesenchymal cells with no evidence of differentiation. As such, they represent the most primitive paediatric sarcoma described to date and form an attractive model to study the early molecular and genetic aberrations involved in sarcomagenesis.
My analyses have led to a greater understanding of these tumours, and along with my collaborators, I have led one of the first groups to discover the poorly-understood CIC-DUX4 fusion transcript in a large series of PRCSs, and has lead to the discovery of a CIC-translocated family of sarcomas.
I am currently focusing on the design and implementation of cutting edge diagnostic techniques to pediatric sarcomas, including array-based assays, nanotechnology and sequence-based technologies. Such assays will improve diagnostic accuracy and allow much greater genetic information to be obtained from smaller tissue samples.
PRCSs are a unique group of undifferentiated sarcomas composed of primitive mesenchymal cells with no evidence of differentiation. As such, they represent the most primitive paediatric sarcoma described to date and form an attractive model to study the early molecular and genetic aberrations involved in sarcomagenesis.
My analyses have led to a greater understanding of these tumours, and along with my collaborators, I have led one of the first groups to discover the poorly-understood CIC-DUX4 fusion transcript in a large series of PRCSs, and has lead to the discovery of a CIC-translocated family of sarcomas.
I am currently focusing on the design and implementation of cutting edge diagnostic techniques to pediatric sarcomas, including array-based assays, nanotechnology and sequence-based technologies. Such assays will improve diagnostic accuracy and allow much greater genetic information to be obtained from smaller tissue samples.
研究兴趣
论文共 49 篇作者统计合作学者相似作者
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PEDIATRIC AND DEVELOPMENTAL PATHOLOGYno. 1 (2024): 3-12
Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Societypp.10935266231221903-10935266231221903, (2024)
Aida I. Glembocki,Gino R. Somers
PATHOLOGYno. 2 (2024): 283-296
Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Societypp.10935266231199928, (2023)
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Anita Nagy,Gino R. Somers
Surgical Pathology Clinicsno. 4 (2020): 763-782
user-5f8411ab4c775e9685ff56d3(2020)
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