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个人简介
Gilles Vergnaud started his scientific career at the Pasteur Institute in 1982 and has since been involved in public health research in the field of genomics, with the aim to associate basic science and applications. He first worked on the development of genetic maps for the human genome starting from the Y chromosome during his PhD. work and expanded his investigations to the whole genome in subsequent years. Maps were constructed by genetic linkage using polymorphic tandem repeat markers (VNTR). VNTRs were detected and isolated by means of synthetic tandem repeats made from random oligonucleotides concatenated in vitro and used to probe the human genome. G. Vergnaud also used these tools to create genetic maps in other mammalian species and to detect chromosomal rearrangements associated with mental retardation.
In collaboration with Alain Nicolas, he investigated in a yeast model the mechanism of instability of tandem repeats found to be highly unstable during human meiosis, demonstrating the role of DNA double-strand-breaks in the process.
In 1997, G. Vergnaud moved to University Paris-Sud in Orsay (now part of University Paris-Saclay) and became interested in studying the genetic diversity of bacterial pathogens. He took advantage of the availability of the first fully sequenced bacterial genomes and of bioinformatics tools to investigate systematically the presence of VNTRs which could be used to genotype bacterial pathogens. He together with Christine Pourcel and a number of collaborators in France and abroad applied these tools to the classification of hundreds of strains from a few major human pathogens including Mycobacterium tuberculosis, Bacillus anthracis, Brucella, Yersinia pestis.
This approach allowed him to identify previously unknown lineages of high value to understand the phylogeny of these pathogens. Another important consequence of this line of work was the discovery of the function of CRISPR-Cas systems published in 2005.
Since 2010, G. Vergnaud started taking advantage of the newly accessible whole genome sequencing technologies to investigate the evolution and phylogeography of pathogens he previously characterised using tandem repeats polymorphisms.
In parallel since 2009, G. Vergnaud contributed to the efforts led by Christine Pourcel in characterizing bacteriophages. In particular, he has applied high throughput sequencing to investigate the role of phages in the transduction of bacterial DNA and to better understand the importance of pseudolysogeny in phage-bacteria co-evolution.
G. Vergnaud has contributed to the development of a number of web sites related to bacterial genomics, genotyping and CRISPR analysis.
研究兴趣
论文共 264 篇作者统计合作学者相似作者
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PloS oneno. 6 (2024): e0305569-e0305569
Frontiers in microbiology (2023): 1106994
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Bacteriano. 4 (2022): 242-249
Vitalii Timofeev,Irina Bakhteeva,Alexander Mokrievich,Galina Vakhrameeva, Elena Gritskova, Yuriy Anisimov, Evgeny Rozhdestvensky,Galina Bazarova,Rostislav Zhumakaev,Ivan Dyatlov,Gilles Vergnaud
crossref(2022)
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